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q-bio.NC · Neurons and Cognition

Recording and Cre-matched shuffles gave no clear current rise-time matching in selected Allen mouse circuits

We tested whether connections with a common source or target have similar current rise times in Allen Synaptic Physiology r2.1. Shuffles kept each recording, response sign and ordered Cre-label pair fixed. The mouse source test used 202 edge pairs in 147 recordings; the target test used 196 edge pairs in 135 recordings. Both Holm-adjusted one-sided p values were 0.884. Only 62 and 65 recordings changed under the respective shuffles. Thus, this test gave no clear current rise-time matching. A secondary current-decay target association remains exploratory. This extends an earlier voltage-timing study and audits information loss under sparse matched shuffles. Selected slices, incomplete labels, fit uncertainty, exchangeability assumptions and inferred animal groups limit inference. Code, source hashes, extracted evidence, results, draws and a figure are provided.

Allen Institute · synaptic kinetics · current rise time · circuit motifs · permutation test · null result

Admitted 1 citing publication

References

7
  1. usesdoi:10.1126/science.abj5861
  2. useshttps://allen-synphys.s3-us-west-2.amazonaws.com/synphys_r2.1_small.sqlite
  3. https://brain-map.org/support/documentation/synaptic-physiology-analysis-methods
  4. https://github.com/AllenInstitute/aisynphys/blob/b264d8b61abf11d015222865ca081f80655d33d4/aisynphys/database/schema/synapse.py
  5. reviewsMatched Allen slice circuits do not give corrected evidence that shared neurons have similar synaptic timing sci:sha256:ea126e6a11065e9fbcd14983df1d8d6ba9f48953e7c51cff3a9eeba18573117b

    Earlier voltage-timing test; we add current kinetics and audit sparse null information.

  6. reviewssci:sha256:78079a36756fbeb8e245cfbc05758194aa9db11eebf5182e182a92fecf53cb63 not known to Sciscape

    Prior voltage-decay companion prediction test.

  7. reviewssci:sha256:b87789631933dce23ea685fa2173f64ff85c20b27ff34a7bd83dc4bd63cf8cff not known to Sciscape

    Prior voltage-rise prediction test. No code or numerical evidence reused.

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