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q-bio.NC · Neurons and Cognition

After plane mean removal, traced sister cells had excess repeat correlation in two of three mouse olfactory recordings

We tested whether cells with a traced common glomerulus shared response changes across repeated odors. We used calcium response means and anatomical labels from three anesthetized mice. The primary analysis covered 44 groups and 277 sister pairs within imaging planes. We subtracted pre-odor levels, each cell's mean response to each odor, and the plane mean deviation. Sister minus nonsister residual correlation was +0.214, +0.158, and -0.006 in the three recordings. The equal-mouse mean was +0.122. A conditional group resampling range was +0.078 to +0.162. The mean exceeded all 9,999 label reference draws within planes. Before plane mean removal, the mean variance of sister-cell averages relative to a zero-covariance prediction was 1.375, 1.390, and 1.011. Matching odor tuning reduced the largest recording's correlation excess to +0.091. Broad repeat-offset removal left the two positive effects largely unchanged. A later distance and tuning match gave sparse coverage in the smaller recording. Shared activity has strong prior evidence in olfactory circuits. This contribution adds a checked mouse repeat-covariance dataset, explicit plane and tuning controls, and variance ratios for averaging. The results concern slow calcium signals from these recordings. Few repeats, three mice, shared state, and fluorescence contamination limit their interpretation as neural noise. The package preserves inputs, source hashes, code, all result tables and reference draws, figures, and repeat instructions. Every input mean matched the primary data. A fresh run reproduced all 17 generated numerical files byte for byte.

olfactory bulb · structure and function · sister cells · repeat covariance · shared input · calcium imaging · noise averaging

Admitted 4 citing publications

References

7
  1. usesdoi:10.1101/2025.04.24.650439

    The source study supplies measured calcium activity and traced glomerular membership in three mice. It already reports common tuning and response diversity.

  2. usesdoi:10.5281/zenodo.15150149

    This fixed source record supplies all primary response arrays and anatomical labels. We checked every bundled mean against the original arrays.

  3. usesKeeping full cell responses raised mean odor decoder accuracy by 0.96 percentage points over one fitted component in 67 sister groups from three mice sci:sha256:212bb73e308009c4916a3a0417591e9c158671f17325fc89fe6122b045853509

    We verified this package and used its checked compact response means. Our outcome is within-odor repeat covariance and its effect on averaging variance.

  4. usesWith odor gains fitted, shared glomeruli cut mean 0 to 5 s calcium trace test error by 4.0% against plane controls in three mice sci:sha256:790915f0b5b4807c0d707a55a5837467a478fddaf44aeef5325d53073ffbb686

    This verified package supplies factual soma coordinates and their source records for later spatial controls. It also gives the earlier response extraction and transfer analysis.

  5. sci:sha256:385f19ee257a3cb771a2753ed873ca2a40daf2922921f123939d3defb320b0c8 not known to Sciscape

    This related analysis estimates stable response errors. Its independent-repeat assumption concerns errors between repeat sets. Our cross-cell covariance result does not test that assumption.

  6. supportsdoi:10.1038/nn.2376

    Earlier fly recordings linked common glomerular input to correlated activity and consequences for averaging.

  7. supportsdoi:10.1073/pnas.1303830110

    Earlier mouse recordings show how respiration, population activity, and recording position affect residual correlations. These factors limit mechanistic interpretation here.

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