Pairs of distinct contacts gave a 79–81% smaller birth-to-adult fall in partner agreement for 91 C. elegans neurons
We tested how pair selection changes input and output partner concentration in eight C. elegans brain maps. We used a fixed set of 91 embryonic neurons with at least two contacts per direction in every map. A contact was one synapse site to one distinct target. With replacement, input agreement fell by 0.14767 from the birth map to the mean of two adult maps. With two distinct contacts, it fell by 0.02810. The fall was 81.0% smaller. The output fall was 79.1% smaller under the same rule. Stricter neuron sets could change the sign. Uniform site selection also changed output values. An exact copy control showed that excluding self-pairs can change a score when partner proportions stay fixed. The pair rules answer different questions; neither identifies a uniquely correct biological age effect. All 208,656 tested source workbook entries matched the listed-entry extraction. Exact enumeration, an independent site matrix calculation and a clean 26-file repeat passed. The package has code, aggregate data, figures, source hashes, formulas and repeat instructions. This is an exploratory comparison of recorded maps from different animals, with only two adults. It does not test a population age effect or repeat the original study's recurring-connection growth test.
connectome · Caenorhabditis elegans · development · partner concentration · Simpson concentration · synapse sites · sampling · reproducible methods
References
5- usesdoi:10.1038/s41586-021-03778-8
We use the eight source synapse lists, the neuron classifications and the count workbook at Git commit 0646af9d25896ae660f97d462eab2d67282f5625.
- usesdoi:10.1038/163688a0
We use the established distinct-pair concentration formula and state its finite-map meaning.
- Uniform samples of 588 synapse sites gave 668 and 678 expected connections in two adult C. elegans graphs of 162 embryonic neurons sci:sha256:e70e91343c11f134c3279afec959a04240686b1c5070959d509ce5cb10d93804
[Legacy relation: reproduces] All 24 graph totals for the eight 162-neuron maps matched. That work tested connection counts; we test input and output concentration.
- supportsSampling rules changed the sign of the bilateral weight overlap difference in 150 neurons from four L1 C. elegans brains sci:sha256:160fdc26d61dd2fd3ee95c5811a9477fdf6d4a56c2321cebc0b4a18b96256358
It showed that sampling rules and proportional copies can alter bilateral overlap. We test those distinctions for partner concentration.
- supportsShared synapse sites increased target count variance in eight C. elegans maps under an independent site loss model with probability 0.5 sci:sha256:399bdcad1d87baa2a47b9dd65985f85e0e1649a4a98020a858f7efea7cba46ee
It showed why synapse site groups matter for a joint target outcome under a loss model. We retain sites but use pair selection rules instead of a biological loss model.
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