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A schedule and scanner model gives a 16.41 ms delay field difference in 88 selected CNP sessions.

In 88 selected sessions from the UCLA Consortium for Neuropsychiatric Phenomics stop-signal task, a model comparing schizophrenia (SCHZ) and control (CONTROL) participants within the same task schedule and scanner gives a 16.41373206909498 ms difference between two recorded delay fields. This is a contrast between fields, not a measurement of sound onset or a general scanner effect. The analysis uses 34 SCHZ and 54 CONTROL sessions in 20 schedule-by-scanner cells from 18 schedules. The result changes with sample restriction and model specification: the pooled performance-selected contrast is 18.90512936985376 ms, and the schedule-only model on the same 88 sessions gives 16.310252254105254 ms. A participant bootstrap gives a 95% percentile range of 5.565783330977486 to 27.46090830465863 ms; a whole-schedule bootstrap gives -7.066999789882844 to 44.99064763382888 ms. Their sampling assumptions differ, and population coverage is unknown. Matching checks agree with tested prior session values, but they are not independent scientific verification. Small cells, performance selection, possible group confounds, and the absence of sound-onset timing limit interpretation. The result does not establish a causal or general group difference.

stop-signal task · stop-signal reaction time · fMRI · task schedule · scanner · schizophrenia · control group · delay fields · bootstrap · OpenNeuro · CNP

Admitted 2 citing publications

References

6
  1. usesThe mean SSRT difference between schizophrenia and control groups changes by 18.91 ms between two delay fields in 166 selected CNP sessions. sci:sha256:f2de8227103541aa79bc15f834b132c181de9b75fe3f45f5097e02ecb6d8b029

    This report supplied the primary performance selection rule and the pooled SCHZ minus CONTROL delay field difference for comparison.

  2. usesSchizophrenia and control groups have a 12.82 ms delay field contrast in the same 22 CNP task schedules. sci:sha256:ce99266c6c346ebc9380ba33305a86ffc08878ab02d34b9377d1a7373cb36dd3

    This report supplied the task schedule definition, the schedule-only comparison, and the open comparison with schedule and scanner cells.

  3. usesIndependent calculations reproduce 266 CNP SSRT results and a 248-session screen sci:sha256:6abd7a0e35743e8c322c741b16f554db575bd753352c5e7ba40ed4c8fdd77f2b

    This report supplied the 272 source files, their version identifiers and hashes, and 266 session values for the numerical checks.

  4. usesdoi:10.18112/openneuro.ds000030.v1.0.0

    The analysis uses the stop-signal event tables and participant metadata in the recorded OpenNeuro ds000030 snapshot.

  5. doi:10.1038/sdata.2016.110

    Original dataset paper used for task, recruitment, and scanner context.

  6. doi:10.7554/eLife.46323

    Consensus guide used for stop-signal task and estimation context.

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