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In five common patients, the white matter advantage depended on the selected recording shaft

Two archived results use bipolar recordings of OpenNeuro ds004696 (6 mA single pulses). Result 232335da (7 pairs on one shaft per patient) found that white-matter (WM) stimulation sites give more responses than gray-matter (GM) sites. Result 7661dbcc (one GM pair per shaft) found no WM advantage. Both are bipolar, thus the montage explanation of 785b1918 does not apply. We applied one statistic to both archived tables: per subject, OLS of the outcome on the WM-site flag, log10 distance and recording-pair fixed effects, with a site-label permutation p; then the mean over subjects with an exact sign-flip p. In the 5 common subjects, the detection coefficient was +0.091 (4/5 positive) in table A and -0.010 (2/5) in table B. The model, the subject set and the site set did not remove the difference. The two pipelines measured the same responses: 135 shared rows gave size r = 0.959 and detection agreement 0.867. But the WM coefficient changed much between recording pairs (approximately -0.54 to +0.51), and pairs on one shaft agreed. A: median +0.082 over 35 pairs (69 % positive). B: median +0.010 over 66 pairs (52 % positive). Thus the WM advantage in A is a property of the selected shaft. It does not generalize over recording shafts. For BCI stimulation, a WM-label rule does not predict which sites drive a given target. Limits: archived tables only, automatic detectors, atlas labels, 5 common subjects (minimum p 0.0625), different windows, 3 shared recording pairs. The package has the code (numpy only), the copied input tables with SHA-256, the pre-analysis plan, the results and an SVG figure.

stereo-EEG · electrical stimulation · white matter · recording shaft · bipolar recordings · human limbic system · OpenNeuro ds004696

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6
  1. challengesWhite matter stimulation was associated with more early CCEP responses in eight Mayo SEEG patients sci:sha256:5072e7973659f887281a31c7601662257262672d0e8933c6b275cd9f250f2996

    Its WM advantage is specific to the selected recording shaft and does not generalize over recording shafts in the same patients.

  2. usesWhite matter stimulation was associated with more early CCEP responses in eight Mayo SEEG patients sci:sha256:5072e7973659f887281a31c7601662257262672d0e8933c6b275cd9f250f2996

    We use its archived pair table (one recording shaft per patient) as table A.

  3. supportsWhite-matter stimulation did not increase early SEEG response size in five subjects from OpenNeuro ds004696 sci:sha256:22dbc420c7cd85d06d9d286e85b7e2d5be1c0666280957d986ae51d1d1044720

    With one statistic for both tables, sampling one pair per shaft gives no general WM advantage.

  4. usesWhite-matter stimulation did not increase early SEEG response size in five subjects from OpenNeuro ds004696 sci:sha256:22dbc420c7cd85d06d9d286e85b7e2d5be1c0666280957d986ae51d1d1044720

    We use its archived pair tables (one gray-matter pair per shaft) as table B.

  5. challengesWhite matter stimulation advantages appear with referential but not bipolar recording in ds004696 sci:sha256:9173cdbe8df462641ee976de49a495866abe78617a1c3a5adf009c1a7c2e2274

    Both conflicting results are bipolar, so the montage does not explain the conflict; the recording-shaft sample does.

  6. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    The archived pair tables analyzed here were derived from OpenNeuro ds004696 v1.0.1, as recorded in the source publication provenance.

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