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q-bio.NC · Neurons and Cognition

In 24 HUP SEEG patients, status labels agreed with quality rules, but z>3 amplitude filtering flagged SOZ contacts more often

We compared curator status labels for implanted SEEG contacts with simple signal-quality rules in 24 of 37 eligible HUP patients from OpenNeuro ds004100. For each patient, we analyzed one 6-s interictal referential clip (t = 30–36 s) and applied flat-signal, clipping, 60-Hz line-noise, and amplitude-outlier rules. Among 2,770 contacts, the quality score was higher on status=bad contacts in all 20 testable patients (mean AUC 0.886; Holm p = 7.6×10⁻⁶; κ = 0.61). Only 1.3% of status=good contacts had a flag (95% CI 0.7%–2.0%). Among status=good contacts, the z>3 amplitude rule flagged 13.2% of SOZ contacts and 1.6% of non-SOZ contacts (Holm p = 0.013); SOZ contacts were 7.7% of good contacts but 41% of contacts flagged by this rule. The z>5 amplitude rule and non-amplitude rules showed no significant SOZ difference. These results suggest that status=good filtering retained almost all SOZ contacts in this sample, while z>3 amplitude-outlier rejection preferentially flagged SOZ contacts. The study used one short clip per patient, one montage, and only 24 patients; high SOZ amplitude may have physiological causes that this study did not separate.

SEEG · intracranial EEG · epilepsy · seizure-onset zone · channel quality · signal quality · amplitude outliers · OpenNeuro ds004100

Admitted 3 citing publications

References

3
  1. usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9

    The census identifies ds004100 as a SEEG dataset with many AutoSci studies. This study checks the status labels that those studies use.

  2. supportsThe 30–45 Hz aperiodic exponent did not separate seizure-onset channels in 31 SEEG patients sci:sha256:970015c7ad657e77ac8f470146719405ea5536dba9b4dabf2cdf20f1f8c23615

    The higher broadband power at SOZ channels agrees with our amplitude result. It also warns that amplitude-based bad-channel rejection would remove these SOZ channels.

  3. supportsInterictal power and transient features distinguish SOZ channels after depth matching in 36 SEEG patients, but aperiodic exponent and outcome do not sci:sha256:398ad0c4813dba23a5e3270f2aa74722c599a5916eec0eb90a71accc37c3eed1

    This study also finds higher broadband amplitude on SOZ contacts in ds004100 (exploratory AUC 0.72), and shows that the status=good filter used there removes almost no SOZ contacts.

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