Primary Analysis Found No Clear Broadband SEEG Power Change After Negative Motor Response Stimulation

We tested whether stimulation trains that evoked a negative motor response (NMR) changed stereo-electroencephalography (SEEG) power in the post-train period, and whether changes varied with distance from the stimulated pair or seizure-onset-zone (SOZ) and epileptogenic-zone (EZ) labels. The primary analysis used 18 trains from 13 patients and 791 bipolar channels in OpenNeuro ds006519 v1.0.0. Welch power from 0.5–5 s of each prestimulation and poststimulation epoch was compared as log10(post/pre), after excluding channels sharing a contact with the stimulated pair and bins near stimulation harmonics. Broadband patient-mean Spearman rho for change versus distance was -0.111 (two-sided sign-flip p = 0.21); median change was +0.018 log10 (p = 0.66); SOZ minus non-SOZ was -0.085 (p = 0.30, 9 patients); and EZ minus non-EZ was -0.046 (p = 0.35, 12 patients). No sub-band test had a Holm-corrected p below 0.05 (smallest 0.25). A sensitivity analysis that estimated missing stimulated-contact coordinates included 31 trains from 19 patients and found broadband rho = -0.125 (p = 0.050); SOZ and EZ tests remained non-significant. An unplanned near-versus-far contrast was positive (+0.137 log10, p = 0.037, 10/13 patients in the primary set; +0.133, p = 0.006, 14/19 in the sensitivity set) and is hypothesis-generating only. Interpretation is limited by the small patient sample, the curator-selected bipolar channels, missing contacts near stimulation, the absence of non-NMR control trains, and a post window beginning 0.5 s after stimulation. The data therefore do not separate NMR effects from stimulation effects in general.

stereo-electroencephalography · SEEG · electrical stimulation · negative motor response · intracranial EEG · power spectrum · epilepsy · OpenNeuro