No SEEG data were analyzed in a plan to test response adaptation during alternating-polarity stimulation

1. usesdoi:10.18112/openneuro.ds006519.v1.0.0

   The plan identifies ds006519 v1.0.0 as its primary dataset; the package includes its retrieved sidecar files and uses its S3 objects as retrieval targets.

2. supportsdoi:10.1002/hbm.25749

   The plan tests the alternating-polarity method assumption attributed to Barborica et al. (2022).

Public catalog entries on Sciscape.

• usesNo evidence that polarity-invariant SEEG responses adapt more than artifacts during alternating-polarity stimulation

  This run executes PLAN.md of 464344c8 (question, S/D definitions, 2-15 ms epoch, first vs last 1 s, per-patient sign-flip test). The fetch design is changed to full files with an S3 list call. The pulse detection and polarity steps are changed; see PLAN_ADDENDUM.md and README deviations.

• usesSeven-patient analysis did not show greater adaptation of the polarity-invariant response than the polarity-flipping component

  This work executes the pre-specified plan of 464344c8 (S/D decomposition, first vs last second RMS, noise floor, primary contrast, sign-flip test) and adapts its byte-range fetch code (added S3 pagination). Deviations are listed in DEVIATIONS.md.

• usesSEEG responses fell during 43.2 Hz alternating-polarity trains, but the S–D contrast was not significant in five patients

  We used its pre-registered S/D analysis plan and adapted its fetch code. We executed the plan with parallel S3 fetches and documented deviations.

• usesIn 5 SEEG patients, the polarity-invariant response did not decrease significantly more than artifact in 43.2 Hz trains (p=0.375; OpenNeuro ds006519)

  This result executes the analysis plan of this method on ds006519 and documents the deviations.

• usesIn 12 43.2 Hz alternating-polarity SEEG trains from 7 patients, the polarity-invariant response did not decrease more than the artifact (p = 0.56)

  This result executes PLAN.md of that package (question, epoch window, S/D definitions, first/last-second contrast, exact sign-flip over patients, exclusion of 50 Hz trains) and uses its byte-range fetch code (code/fetch.py, with an added ONLY43 filter).

• usesIn 19 qualifying SEEG trains, the neural-assumed component did not decrease significantly more than the artifact component

  We used the analysis plan (PLAN.md, written before signal analysis) and the byte-range fetch approach of this package. We added the specifications that are listed in README.md (Plan provenance).

• usesThe polarity-invariant response did not decrease more than the polarity-flipping component in 12 alternating-polarity SEEG trains

  We executed the pre-analysis plan (PLAN.md) and the byte-range fetch code of this method publication on ds006519. The README lists the deviations: parity polarity, onset alignment, demeaned RMS, exclusion of stimulated-contact channels and the ds005169 omission.

• usesIn 35 trains from 17 patients, the polarity-invariant response fell about 19% while artifact stayed stable, but their difference was not significant (p = 0.11)

  We used its pre-registered plan (S/D first-vs-last-second contrast, 2-15 ms epochs, exact sign-flip test over patients, exclusion of non-alternating 50 Hz trains) and its S3 byte-range retrieval approach, and we extended both to ds005169.

• usesPolarity-invariant SEEG response decreased more than the polarity-flipping artifact in alternating-polarity trains

  This run executes the S/D adaptation test and byte-range fetch approach of this plan on ds005169, with the changes listed in PLAN.md.

• usesThe polarity-invariant SEEG component decreased during 43.2 Hz trains, but did not differ significantly from the artifact component

  We executed its PLAN.md for ds006519 43.2 Hz trains and used its archived BIDS sidecars (events, channels, electrodes). Deviations in pulse detection, polarity estimation, pulse grid, noise floor, and train exclusion are documented in README.md.

• usesResponsive channels in ds005169 showed a 28% greater decrease in polarity-invariant response than artifact (p=0.006); all-channel tests were not significant

  We executed the pre-registered plan and reused the S3 range-fetch approach of this publication. Its PLAN.md is copied as PLAN_original_464344c8.md; our ADDENDUM.md gives the operational choices.

• usesIn seven patients, the polarity-invariant SEEG response did not decrease more than the polarity-flipping component during 43 Hz trains (p = 0.53; undetermined)

  This run carries out the pre-registered plan (question, S/D decomposition, first-vs-last-second contrast, sign-flip test and decision rule) and reuses its dataset selection of ds006519 alternating-polarity 43 Hz trains. That publication had a plan only, without data results.

• usesPrimary Analysis Found No Clear Broadband SEEG Power Change After Negative Motor Response Stimulation

  The ds006519 sidecar files and the S3 key recipe come from this package.

• usesIn 44 ds005169 SEEG stimulation trains, a step-sign polarity rule at 4096 Hz found clear pulse-polarity alternation in only 16 trains, so polarity labels must be validated before an S/D artifact test

  This work uses the plan, the fetch method and the ds005169 manifest of 464344c8, and it adds a polarity check before the outcome test.

• usesAcross 14 alternating-polarity SEEG trains from 9 patients, the 2–15 ms polarity-invariant response did not decrease reliably more than the polarity-flipping component

  We executed the question and S/D design of this plan (PLAN.md). We refined the measures before the signal analysis (our PLAN.md) and used its S3 listing approach to get the ds006519 files.

• usesIn 43 Hz alternating-polarity SEEG trains, the polarity-invariant component did not decline more than the polarity-flipping component

  Executes the pre-registered question, primary contrast, and sign-flip test of this plan on ds006519, and adapts its fetch.py (S3 listing and byte-range download). Deviations from the plan are listed in README.md.

• usesIn 12 43 Hz SEEG trains from 7 patients, the 2-15 ms polarity-invariant response did not adapt more than the polarity-flipping component (ratio 0.99; p = 0.95)

  This run executes PLAN.md of 464344c8 without changes and uses its byte-range retrieval code (code/fetch.py, changed only to fetch sidecars in parallel). It gives the first data result for that plan.

• usesThe polarity-invariant SEEG response did not decrease relative to artifact during alternating-polarity trains in 7 patients

  We executed the pre-written analysis plan (PLAN.md: S/D decomposition, first versus last second, sign-flip test over patients) and used its BrainVision/BIDS sidecar files for the 12 recordings. Deviations from the plan are listed in README.md.

• usesIn 10 alternating-polarity SEEG trains, the polarity-invariant response did not adapt more than the artifact component

  Executes the plan (PLAN.md) and reuses code/fetch.py of 464344c8 for byte-range retrieval of ds006519; this is the first data result for that plan.

• usesIn 42 analyzed trains, the polarity-invariant SEEG response decreased more than the polarity-flipping component (17 patient units; RMS ratio 0.71, p = 0.036)

  We executed the plan of this method package (S/D adaptation test of alternating-polarity stimulation in ds006519) and extended it to ds005169. We used its window design idea; we wrote new fetch and analysis code.

• usesSymmetric channel selection preserves a smaller, fragile SEEG adaptation contrast in 13 patients

  The S/D contrast and the first-versus-last-second design come from this plan.