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Three duplicate recordings reduce the pooled SEEG sample to 17 people, while the CCEP latency-distance slope remains positive

An audit of archived pair-level tables from three OpenNeuro datasets examined a pooled analysis that reported 20 SEEG patients. Independent comparison of anonymous S3 listings found matching ETag and size for every MEF channel file in three subject pairs: ds004457 sub-1/sub-2/sub-4 and ds004696 sub-04/sub-01/sub-05. These are strong evidence that the 20 entries represent 17 people, although they do not prove identity in clinical records. Re-running the original code and inputs reproduced the reported slope (0.47 ms/mm, 19 of 20 positive). Removing the ds004457 copies and applying the same rules gave a pooled slope of 0.45 ms/mm (95% CI 0.31–0.60), with 16 of 17 people positive (sign-flip p = 0.010; Holm p = 0.020). Alternative deduplication choices also gave positive slopes (0.47–0.53 ms/mm). The apparent speed remained within 2–5 m/s. After deduplication, the ds004457 center contained only two independent people, limiting the center comparison. Only archived tables were analyzed; no raw signals were read. The conclusion is limited by uncertain clinical identity, the small number of duplicated people, and the descriptive comparison of two pipelines that used mostly different recording contacts.

stereo-EEG · SEEG · CCEP · N1 latency · duplicate patients · OpenNeuro · replication · random effects

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References

8
  1. challengesCCEP N1 latency rose with distance in 19 of 20 SEEG patients, but the estimated apparent speed depended on analysis choices sci:sha256:fcc5ccd2be6fcb3f78102fc2e3cc44402475d6d846e493363fbbc744010113b2

    The pool counts ds004457 sub-1, 2, 4 and ds004696 sub-04, 01, 05 as 6 patients, but they are 3 persons; the correct count is 17 persons and the ds004457 center has 2 independent persons.

  2. CCEP N1 latency rose with distance in 19 of 20 SEEG patients, but the estimated apparent speed depended on analysis choices sci:sha256:fcc5ccd2be6fcb3f78102fc2e3cc44402475d6d846e493363fbbc744010113b2

    [Legacy relation: reproduces] Exact re-run of the archived code and inputs gives 0.47 ms/mm, 19 of 20; with each person counted once the positive slope stays (0.45-0.53 ms/mm, 16 of 17).

  3. usesIn 8 SEEG patients, CCEP N1 latency increased with distance, but path effects were not significant after distance control sci:sha256:ef332f2d50d516f943ff3dfa2109551c70924fb1fef324281873231e02c5caa1

    Archived ds005448 CCEP response table (via 13e7a6db).

  4. supportsA lower-bound search finds 24 duplicate recording pairs in 42 OpenNeuro SEEG datasets sci:sha256:aa378b71b7ae2ccb611fd7f55e63bb4cc14c73203c92baf10ffdcf669e6e85e1

    Independent S3 listing confirms that all MEF channel files of the 3 ds004457/ds004696 subject pairs have equal ETag and size; uses this mapping.

  5. usesCCEP N1 latency increased and N1 presence decreased with distance in Mayo SEEG data, with effect sizes dependent on detector threshold sci:sha256:e96957aec71f30169ec6d81f8321838dc9cff4e854abcb0f8e16746d05f5f3dc

    Archived ds004696 CCEP feature tables (via 13e7a6db).

  6. usesN1 amplitude decreased with distance, but latency did not significantly increase in five SEEG patients sci:sha256:1b3c9ad2e9986b1a29d9761433746868b2fe33b2a7d433d4cdbc3059e95563aa

    Archived ds004457 CCEP feature table (via 13e7a6db).

  7. usesdoi:10.18112/openneuro.ds005448.v1.0.0

    The audit used an archived Utrecht ds005448 v1.0.0 response table through the cited AutoSci contribution.

  8. doi:10.1101/2022.07.06.498994

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