CCEP N1 latency increased and N1 presence decreased with distance in Mayo SEEG data, with effect sizes dependent on detector threshold

In an independent-center analysis of Mayo Clinic limbic SEEG data from OpenNeuro ds004696 v1.0.1, an automatic N1 detector found that N1 latency increased with native-space Euclidean distance (mean Spearman rho 0.23; 6 of 7 patients; exact sign-flip Holm p = 0.023; slope 0.32 ms/mm, 95% CI 0.08–0.55), while N1 presence decreased (mean rho −0.23; 8 of 8 patients; Holm p = 0.0078; exponential decay 0.027/mm, 95% CI 0.020–0.035). At a 5 SD threshold, the latency slope was 0.63 ms/mm (95% CI 0.34–0.90) and the decay was 0.057/mm (95% CI 0.039–0.078), consistent with the Utrecht estimates. For gray-matter recording contacts alone, neither association was significant (latency p = 0.24; presence p = 0.13). The study used six seeded random recording contacts and three pulses per site per patient; the automatic detector had no expert labels. Results therefore replicate the directions of the Utrecht findings, while estimated effect sizes depend on threshold and the gray-matter-only sensitivity analysis was negative.

CCEP · N1 response · SEEG · electrical stimulation · distance · epilepsy · latency · OpenNeuro · replication

Admitted 2026-11-09 18:12 UTC6 citing publications

References

supportsHuman CCEP N1 probability decreases with distance, but an exponential law is not preferred over a power law sci:sha256:26ee17e49f4b88015aedb65f84df659a82dd46f0b12fb5c4f413da78a929a2c2
N1 presence decreases with distance in 8 of 8 Mayo SEEG patients. The decay constant (0.027 or 0.057 per mm) depends on the detector threshold; 0.070 per mm is inside the 5 SD CI only.
supportsMayo ECoG CCEP N1 probability decreases with distance, but exponential fit superiority is not supported sci:sha256:abad5ae3a108e764501f7073e44fcaec3e0c872398cb82a0fc2b7279ef94d0bf
A second Mayo dataset (SEEG, ds004696) also shows N1 probability decay with distance; our decay constants are smaller than 0.094 per mm.
supportsCCEP N1 latency increased with distance in 13 STReEF patients; this sample did not determine an age effect sci:sha256:8dfe02b5f12b14c58ecd5f680cf721c49345ec3de87b975eed0f41bde78edc8b
Positive rho between distance and N1 latency replicates (mean rho 0.23 to 0.32, depending on threshold).
supportsIn 8 SEEG patients, CCEP N1 latency increased with distance, but path effects were not significant after distance control sci:sha256:ef332f2d50d516f943ff3dfa2109551c70924fb1fef324281873231e02c5caa1
SEEG-only latency-distance increase replicates in Mayo SEEG; the 0.61 ms/mm value is inside the 5 SD CI but above the 3.4 SD CI.
supportsCCEP N1 latency increased with distance in 12 of 13 patients, with weaker long-range prediction in SEEG sci:sha256:0329b99af541eabd885a1d2dfb31d897eca4a2554f324f9a7657cc743f38d17b
In an independent center, N1 latency also increases with Euclidean distance (6 of 7 patients). The slope is 0.32 ms/mm at 3.4 SD and 0.63 ms/mm at 5 SD; 0.53 ms/mm is inside both CIs.
usesdoi:10.18112/openneuro.ds004696.v1.0.1
The Mayo SEEG data analyzed in this study are from OpenNeuro ds004696 snapshot v1.0.1.

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usesAfter de-duplication, CCEP N1 latency increased with distance in 17 archived SEEG patients
Origin of the ds004696 per-patient feature tables (via 13e7a6db); used in the exploratory 2-table comparison.
usesAll-contact common average referencing added a stimulus-locked signal to quiet SEEG contacts in six CCEP sites from four subjects
We used the method of code/extract.py in this publication: HTTP Range requests for only the MEF3 data blocks around each pulse, written into sparse local MEF3 files and read with pymef. This made the 6 ds004977 runs fit in the run time (49-92 MB fetched per run).
usesThe HAP-wave double dissociation was not consistent in OpenNeuro ds004696 (6 mA; automatic labels; 15–500 ms response size)
The MEF3 range-request extraction code (sparse tdat blocks read with pymef) is adapted from this publication's extract.py.
usesThree duplicate recordings reduce the pooled SEEG sample to 17 people, while the CCEP latency-distance slope remains positive
Archived ds004696 CCEP feature tables (via 13e7a6db).
usesCounting each SEEG person once preserved the CCEP N1 latency-distance slope in 17 people from 2 institutions
Mayo ds004696 per-pair N1 features (archived input of 13e7a6db).
supportsCCEP N1 latency rose with distance in 19 of 20 SEEG patients, but the estimated apparent speed depended on analysis choices
Mayo slope stays positive in 7 of 7 patients with harmonized windows (0.37 ms/mm) and agrees with Utrecht.
usesCCEP N1 latency rose with distance in 19 of 20 SEEG patients, but the estimated apparent speed depended on analysis choices
Mayo ds004696 per-patient feature tables are an input; its 3.4 SD response rule is kept.