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q-bio.NC · Neurons and Cognition

Minutes with more STE HFO marks on other shafts gave an uncertain SOZ rank change within shafts in 17 SEEG sleep records

We tested whether minutes with more high-frequency oscillation (HFO) marks on other electrode shafts give better seizure-onset zone (SOZ) channel rankings. Time selection excluded the entire target shaft and used no SOZ labels. The source was the first hour of 18 public SEEG sleep records from OpenNeuro ds005398 version 1.1.3. Seventeen records had mixed-label shafts. The primary comparison used 30 high and 30 low weighted minutes, 38 shafts, and 285 channels. The mean STE high-minus-low AUC difference was -0.039. Its 95 percent patient bootstrap interval was -0.102 to +0.024. High minutes held more target events, but a ranking gain was not established. All five planned sensitivity analyses had negative mean differences. The package preserves public source bytes, exact time weights, code, provenance, all results, figures, and offline instructions. All 94 pinned source files or headers matched a new public check. Independent rank checks and an offline repeat passed. This small clinical cohort does not establish clinical benefit or an absence of change.

high-frequency oscillations · seizure-onset zone · stereo-EEG · intracranial EEG · event yield · channel ranking · time selection

Admitted 1 citing publication

References

8
  1. uses20 ms detector matches gave an uncertain SOZ rank gain over combined counts in the first hour of 18 SEEG sleep records sci:sha256:e2fb21fc2b8904e6e332f4adef0382d28035541049ea83d70d8da9f15b9adbb1

    Its source manifest and retrieval rules were preserved through the immediate source archive. Our new curl program uses those fixed Git and S3 pins and EDF header ranges.

  2. usesSEEG power comparisons within fixed shafts give expected AUC 0.5 for independent uniform fixed-count labels and valid other-shaft references sci:sha256:1fbc71bfce5bfe56454619d9a3d155d93e13c5bd8f27c3a86beb29eece2303dc

    Its conditional random-label result for within-shaft AUC informed the scope discussion. We read it after outcome calculation. It supplied no code, data, or analysis change.

  3. usesTen one-minute samples spread across an hour gave an uncertain mean SOZ AUC gain over a continuous ten-minute sample for STE HFO counts in 18 SEEG sleep records sci:sha256:af08abad6a5d6d676a6782296ab206c5f0d8b61bf3e9898a285c96d95f79ff0b

    This work selected the reused 18-record SEEG cohort and tested spread versus continuous samples. It informed the sampling question and source lineage. We add no new patient observations.

  4. usesEqual rate Poisson tests rejected 31 percent of uniform minute assignments on average for STE HFO counts in 18 SEEG sleep records sci:sha256:967277f638229028b293296b1a3234411f8ad8274df96e8153bd9900db30c5f4

    Its pinned source archive, source manifest, and minute counts supplied the 18-record cohort. We rebuilt and checked counts, added shaft and SOZ labels, and tested a new time selector. The source read and event rules informed the extraction code.

  5. usesdoi:10.18112/openneuro.ds005398.v1.1.3

    The analysis uses the public event marks, channel labels, and metadata from OpenNeuro ds005398 version 1.1.3.

  6. doi:10.1111/epi.18545
  7. doi:10.1111/j.1528-1167.2008.01784.x
  8. doi:10.1038/s41467-018-04549-2

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