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For fixed odor panels, amygdala response ranks reduced valence error in pooled human neurons and on average in three fMRI adults

We tested whether relative amygdala responses predict valence for odors excluded from training. Discovery used one released panel of 622 human amygdala units without donor labels. A fixed study test used separate fMRI data from three adults, with 160 odors per person. Sites were scaled with training odors. The reader kept only their response order. Error fell 18.22% in the 15-odor neuron panel and 3.61% on average in fMRI. Individual MRI changes were -6.87%, +15.86%, +1.85%. The conditional shared label test passed, p=0.0027. The 95% person Student interval for MRI mean skill was -24.87% to 32.10%. The result does not establish performance across the human population. The neuron release cannot support donor uncertainty. Separate cohorts, unequal odor panels, different rating targets, clinical sampling, and measurement filters limit scope. Intensity checks and all negative scores remain. This is a new response-order test in reused studies. Earlier work already established odor-valence coding. The package gives code, permitted neuron inputs, external MRI source pins, all results, figures and repeat steps. No common neural cause or causal effect is established.

olfaction · amygdala · single neurons · fMRI · response ranks · valence · odor identity · cross-validation

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References

7
  1. usesdoi:10.1038/s41586-024-08016-5

    Public processed amygdala neuron responses and released reference valence; exact commit and file hashes are preserved.

  2. usesdoi:10.1038/s41593-023-01414-4

    Public processed per-odor MRI responses, ratings, anatomical masks and acquisition sets. Source arrays remain external under their terms.

  3. doi:10.1038/s41467-026-73001-7

    Prior valence and salience analyses used these acquired MRI participants; we do not claim the first odor-valence decoder.

  4. Amygdala decoders generalized across 24-s aversive and neutral blocks in 9 patients, with no evidence of within-block code change sci:sha256:58ad1e203b24fe80cb8b033f31796b0ebf4b96a90a3e10582d746a587aeb8aa2

    Prior amygdala decoder transfer across time motivates a distinct odor-identity transfer question.

  5. usesDuration and gap response orders did not pass a shared positive test in eight ECoG patients and six fMRI adults sci:sha256:b932141c62e93a708035bdcd2dba485dfb67cce195b3e283576b8eb26dc6ef91

    We adapt its MIT bounded-memory MATLAB numeric reader; no visual response data enter the final study.

  6. usesdoi:10.1007/s12078-019-09275-7

    Source of the reference valence vector released by Kehl and colleagues.

  7. doi:10.5281/zenodo.7636722

    Parent raw MRI archive, cited for provenance. Restricted raw data were not accessed.

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