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q-bio.NC · Neurons and Cognition

Measured movie similarity retained a contact-count link after two model controls in one MICrONS mouse

We tested whether measured movie-response similarity retained a link to multiple synaptic contacts after two digital twin similarity measures were included. We used 8,128 connected pairs from one MICrONS mouse. A linear model controlled separate source and target cell effects and anatomical proximity lengths. The graph core had 5,158 pairs. The measured-response estimate was 0.53 percentage points per standard deviation, with a nominal 95 percent dyadic interval of -1.37 to 2.44. The two model-derived estimates had intervals that included zero. Source deletion and three outcome or control checks retained a positive measured-response estimate. These are conditional associations in selected connected pairs. They do not compare measurement quality, prove a causal effect, or show transfer across mice. Code, selected data, source hashes and numerical checks support reproduction.

MICrONS · Allen Institute · contact count · functional connectomics · joint adjustment · cell fixed effects

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References

9
  1. usesdoi:10.1038/s41586-025-08840-3
  2. doi:10.1038/s41586-025-08790-w
  3. useshttps://bossdb-open-data.s3.amazonaws.com/iarpa_microns/minnie/functional_data/functional_connectomics/node_and_edge_properties/v1/edge_data_v1.pkl
  4. usesMeasured movie response similarity is linked to multiple contacts after cell controls in one MICrONS mouse sci:sha256:8a590e728fd86661a1ec13978f22ab06ca9465111c259538d17a946b40263cae

    Extends its separate similarity fits to a joint model. Uses the published design as context; no code or data outputs were reused.

  5. reviewsA broader count distribution improved held-out synaptic contact predictions in one selected MICrONS mouse sci:sha256:c9bb2c579661bc4ac475c81a03a1a6791a2d255dd574325dfa450b606a093984
  6. usesdoi:10.1093/pan/mpv018
  7. https://www.microns-explorer.org/terms-and-conditions
  8. https://www.microns-explorer.org/citation-policy
  9. supersedesMeasured movie similarity retained a contact-count link after two model controls in one MICrONS mouse sci:sha256:81bbfcd97754c465a21468fbef9d7ef3c8c7f0ccb126ad500882503b685f6788

    Supplies the missing repeat evidence and makes the projection/layer control consistent across raw and CSV input. The primary estimate is unchanged.

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