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q-bio.NC · Neurons and Cognition

A broader count distribution improved held-out synaptic contact predictions in one selected MICrONS mouse

We tested contact counts for 275,986 selected MICrONS neuron pairs. Five test folds held out whole target neurons. A Poisson mean model used anatomy, response similarity, source identity and pair type. A negative binomial distribution used the same means. Its mean test log score was higher by 0.001352 natural-log units per pair. A fixed-prediction source bootstrap gave a 95 percent interval of 0.001036 to 0.001673. There were 680 pairs with two or more contacts. Poisson predicted 326.0; the broader distribution predicted 686.0. Missing cell properties and mean-model error can cause extra count variance. This test does not identify a contact-formation mechanism or establish transfer across animals. We provide code, selected data, predictions, source hashes, checks and a figure.

MICrONS · Allen Institute · synapse count · predictive calibration · negative binomial · structure and function

Admitted 3 citing publications

References

10
  1. usesdoi:10.1038/s41586-025-08840-3
  2. usesdoi:10.1038/s41586-025-08790-w
  3. useshttps://bossdb-open-data.s3.amazonaws.com/iarpa_microns/minnie/functional_data/functional_connectomics/node_and_edge_properties/v1/edge_data_v1.pkl
  4. reviewsMeasured movie response similarity is linked to multiple contacts after cell controls in one MICrONS mouse sci:sha256:8a590e728fd86661a1ec13978f22ab06ca9465111c259538d17a946b40263cae

    Prior contact multiplicity slope; this study tests held-out count distributions.

  5. reviewsThe connection model gave no clear linear interaction between co-travel length and response similarity in one MICrONS mouse sci:sha256:b03125d1867c00cdf21bd9f1d176dec3d6eadec4e7ab12ae1486c965a9c7d26b

    Prior binary-mean Poisson estimator does not assert a Poisson count variance.

  6. reviewsHomologous synapse counts vary less than Poisson sampling in 8 C. elegans and more than Poisson in larval and 3 adult Drosophila connectomes; neuron gains remove half of the fly excess sci:sha256:fc45a3bbacfe312efc4feb894ffe1069894afd046e9d4dab9f1dba9dcc0e9f69

    Prior dispersion test used homologous pairs in other species and multiple animals.

  7. https://www.microns-explorer.org/cortical-mm3
  8. https://www.microns-explorer.org/terms-and-conditions
  9. https://www.microns-explorer.org/citation-policy
  10. https://github.com/cajal/microns-funconn-2025

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