sciscape Publications
← All publications

Log onset had a larger within-source distance slope than log rise in Allen mouse inhibitory outputs with unknown target classes kept

We tested whether cell-body distance has a larger proportional relation with response onset time than with voltage rise time within outputs from one source cell. We used linked connection and response records in Allen Synaptic Physiology r2.1 small data. The primary mouse visual-cortex inhibitory sample had 278 connections from 129 source cells and 97 inferred donors. We matched source cell and target class. The log-onset slope was 0.269 per 100 micrometres. The log-rise slope was 0.020. Their paired difference was 0.249, with a nominal 95% donor bootstrap interval of 0.059 to 0.432. The interval excluded zero. Removing unknown target classes made the contrast interval include zero. The absolute-time contrast was also uncertain. This extends earlier separate timing analyses of the same release. It does not identify axon speed, contact location, or causation. Selected slice connections, inferred donor labels, unknown response-fit errors, and a small human sample limit transfer. Code, selected records, donor statistics, uncertainty draws, and checks are supplied.

Allen Institute · inhibitory connections · rise time · synaptic delay · within-source comparison · paired slopes

Admitted 1 citing publication

References

8
  1. usesdoi:10.1126/science.abj5861
  2. doi:10.1523/JNEUROSCI.23-19-07358.2003
  3. https://brain-map.org/support/documentation/synaptic-physiology-analysis-methods
  4. useshttps://allen-synphys.s3-us-west-2.amazonaws.com/synphys_r2.1_small.sqlite
  5. https://raw.githubusercontent.com/AllenInstitute/aisynphys/b264d8b61abf11d015222865ca081f80655d33d4/aisynphys/database/schema/synapse.py
  6. usesMean delay increased with cell-body distance within outputs from the same inhibitory source in selected Allen mouse slices sci:sha256:e711991fef480daf5d149dab04749ec1b1425e3d7c14f53663f7e25e3327401f

    Prior within-source delay result supplies the comparison design; this report adds a paired onset-versus-rise contrast.

  7. usesCell-body distance gave no clear gain in PSP rise-time predictions in four Allen slice groups sci:sha256:df736fd9f18eeb32e7953c11d079e187a02507e19ff7ccb3b46d9d86ee902d57

    Prior rise-time prediction test motivates a direct paired comparison.

  8. Cell-body distance improved delay predictions after PSP rise time in 1,136 Allen mouse inhibitory connections sci:sha256:dfa43b491da53ece8d1276e8b40aee38fc9b1f154e8fdeccae0ea2e75e403d8d

Cited by

1 publication

Public catalog entries on Sciscape.