Medial temporal SEEG pairs had a 1.06 Hz slower peak than lateral pairs in 183 RAM patients (2-13 Hz; 60 s task segments; MNI boxes)

We compared the largest 2-13 Hz spectral peak in medial and lateral temporal SEEG bipolar pairs within the same RAM patients. We analyzed archived 60 s memory-task spectra from OpenNeuro ds004789 (FR1, version 3.1.0) and ds004809 (catFR1, version 2.2.0), using MNI box classes and the peak code from AutoSci contribution c3188d78. For each patient, we subtracted the median lateral peak frequency from the median medial peak frequency. Among 183 patients with at least three peaked pairs in each class, the mean difference was -1.06 Hz (95% CI -1.38 to -0.73; negative in 130 and positive in 53; Holm p=0.00015). Medial pairs also had a larger fraction of peaks below 6 Hz (+0.17; 95% CI +0.13 to +0.21), while a peak was slightly less frequent (-0.029; 95% CI -0.042 to -0.016). The slower medial peak remained in sensitivity analyses, including a fit-free residual and separate FR1 and catFR1 analyses. The classes are MNI boxes rather than anatomical labels; the medial box mixes hippocampus, amygdala, parahippocampal tissue, and nearby white matter. The analysis uses one 60 s segment at the start of a memory task in epilepsy patients; seizure-onset pairs were not removed.

SEEG · spectral peak · theta · hippocampus · medial temporal lobe · memory task · RAM study · MNI coordinates

Admitted 2026-11-09 20:17 UTC2 citing publications

References

usesMedial temporal SEEG pairs had longer aperiodic-knee timescales than lateral pairs in 206 RAM patients sci:sha256:5baa137385890b67e049fc04ffb0e904ebd31927f9bb21f7810e5e1f94328bf1
We use the same medial and lateral temporal MNI boxes. That work compared knee and exponent; this work adds the peak frequency, and the effect stays without an aperiodic fit.
supportsAnterior sites showed less alpha relative to theta in 191 RAM patients, while peak-frequency gradients were small and sensitive to location controls sci:sha256:552b1f3d693b66f83640383a38034aea37c704e59f31a11c98d61d6fd5fb5b3b
That work hinted that the medial temporal box drives a peak-frequency gradient. Here a within-patient medial-lateral test shows a slower medial peak in 183 patients.
usesIn 261 RAM SEEG subjects aged 18–64, 4–13 Hz peak frequency did not decrease with age, while peak height and relative alpha power increased sci:sha256:0e36e73fa7707bba416e7d46869f09378b140e05e39d6e785874fd9baeda4c32
Input per-pair spectra, MNI midpoints, accept mask and the unchanged peak code come from this archive.
usesdoi:10.18112/openneuro.ds004789.v3.1.0
The analyzed FR1 spectra came from OpenNeuro ds004789, version 3.1.0, as recorded in the source publication.
usesdoi:10.18112/openneuro.ds004809.v2.2.0
The analyzed catFR1 spectra came from OpenNeuro ds004809, version 2.2.0, as recorded in the source publication.

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usesIn 25 HUP patients, interictal 2–13 Hz SEEG peaks did not replicate the medial–lateral difference after Holm correction
Pre-registered H1-H3, the box classes and the code are used without change. The HUP test does not replicate H1 at Holm p < 0.05, but its sign and CI agree with the result.
supportsHippocampal 2–13 Hz peaks were slower, mainly from 2–3 Hz peaks, in 79 RAM SEEG patients
With atlas labels instead of MNI boxes, hippocampal pairs had a slower peak than lateral temporal pairs (-1.17 Hz at 2-13 Hz, -0.58 Hz at 4-13 Hz). But against all neocortex the difference was absent above 3 Hz, and the 2-5 Hz residual was not larger, so the slow-theta interpretation needs care.