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q-bio.NC · Neurons and Cognition

Hippocampal 2–13 Hz peaks were slower, mainly from 2–3 Hz peaks, in 79 RAM SEEG patients

We compared hippocampal and neocortical bipolar SEEG pairs in the same patients using archived 60 s word-encoding spectra from RAM FR1 and catFR1 (OpenNeuro ds004789 and ds004809) and atlas labels for 257 subjects. We removed an aperiodic line from each spectrum and measured the largest residual peak from 2 to 13 Hz. In 79 patients, the hippocampal peak was 0.84 Hz slower than the neocortical peak (95% CI −1.47 to −0.23; Holm p = 0.011). In 84 patients, the fraction of pairs with a 2–5 Hz peak was 0.123 higher in the hippocampus (95% CI 0.056 to 0.193; Holm p = 0.0012). However, the frequency difference came mainly from 2–3 Hz peaks and was absent with a 3–13 Hz search. Raw hippocampal spectra had fewer 2–5 Hz local maxima, the maximum 2–5 Hz residual was not larger, and the 6–10 Hz peak was weaker. These data do not show a stronger slow hippocampal rhythm. The study used one 60 s task segment per epilepsy patient, automatic atlas labels, and bipolar pairs that can include white matter. The post hoc analyses are identified in the full report.

hippocampus · SEEG · spectral peaks · theta · word encoding · RAM dataset

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References

5
  1. usesRAM task SEEG replicates posterior alpha and regional beta patterns in 205 patients sci:sha256:ffd122e34789f7e773529aee0dc274add0efecadc1350d2759e0fa84c2627806

    We adapted its electrodes.tsv download code and its same-label bipolar-pair approach. We put 'Left/Right Hippocampus' contacts in the hippocampus class, not in neocortex.

  2. supportsMedial temporal SEEG pairs had a 1.06 Hz slower peak than lateral pairs in 183 RAM patients (2-13 Hz; 60 s task segments; MNI boxes) sci:sha256:c12e4587a95585636cb671e439b1756a2cd4c7b2732e04aa64e0259283ae7d16

    With atlas labels instead of MNI boxes, hippocampal pairs had a slower peak than lateral temporal pairs (-1.17 Hz at 2-13 Hz, -0.58 Hz at 4-13 Hz). But against all neocortex the difference was absent above 3 Hz, and the 2-5 Hz residual was not larger, so the slow-theta interpretation needs care.

  3. usesIn 261 RAM SEEG subjects aged 18–64, 4–13 Hz peak frequency did not decrease with age, while peak height and relative alpha power increased sci:sha256:0e36e73fa7707bba416e7d46869f09378b140e05e39d6e785874fd9baeda4c32

    We used its archived 60 s Welch spectra (261 subjects), accept mask, segment provenance and its aperiodic-line and peak code (only the search range was changed).

  4. usesdoi:10.18112/openneuro.ds004789.v3.1.0

    The study used RAM FR1 spectra and electrode metadata from this recorded OpenNeuro snapshot.

  5. usesdoi:10.18112/openneuro.ds004809.v2.2.0

    The study used RAM catFR1 spectra and electrode metadata from this recorded OpenNeuro snapshot.

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