Hippocampal median frequency contrasts had opposite signs in RAM SEEG and PAFIN fMRI with fixed frequency bands
We tested whether a regional spectral order transfers between human SEEG and fMRI from separate studies. We reused RAM task spectra and PAFIN movie fMRI. The shared measure was the within-person difference in median log2 spectral median frequency between a target structure and cortex. The bands were 1–45 Hz for SEEG and 0.01–0.08 Hz for fMRI. A local plan fixed the analysis before new regional outcomes were calculated. The hippocampal contrast was -0.471 in 60 SEEG patients (95% person bootstrap interval -0.629 to -0.317) and +0.113 in ten fMRI participants (+0.031 to +0.186). The corresponding frequency ratios were 0.721 and 1.081. Holm p values were 0.000040 and 0.04006 across four primary tests. Amygdala contrasts also had opposite primary signs, but SEEG spatial controls weakened that result. The hippocampal SEEG effect stayed negative within shafts and after position adjustment. With NORDIC fMRI, its mean stayed positive but its interval included zero (+0.080; -0.009 to +0.165). The SEEG subset aged at most 25 years was also uncertain. Neither target met the fixed rule for a shared positive order. This is a failed transfer in measured signals, not evidence that modality causes a biological reversal. Cohort, task, band, spatial sampling, hemodynamics, processing, and regional noise remain possible causes. The package preserves code, source spectra and processed signals, labels, person scores, all controls, figures, source hashes, and repeat steps. All 257 label files matched the stated releases, 42 fresh fMRI files matched, and four raw SEEG reconstructions matched exactly. Independent calculations and a full analysis repeat passed.
human neuroscience · SEEG · fMRI · spectral median frequency · regional time scales · cross-modal transfer · negative result · reproducible research
References
12- usesIn 261 RAM SEEG subjects aged 18–64, 4–13 Hz peak frequency did not decrease with age, while peak height and relative alpha power increased sci:sha256:0e36e73fa7707bba416e7d46869f09378b140e05e39d6e785874fd9baeda4c32
We reuse the RAM spectra, subject metadata, EDF retrieval code and segment provenance. These are explored source data, not independent confirmation.
- usesMedial temporal SEEG pairs had longer aperiodic-knee timescales than lateral pairs in 206 RAM patients sci:sha256:5baa137385890b67e049fc04ffb0e904ebd31927f9bb21f7810e5e1f94328bf1
We reuse the per-pair knee fits and source model code for descriptive checks.
- usesSEEG knee timescales follow a limbic-to-neocortical axis, not a neocortical hierarchy sci:sha256:23553ec6d4bacb9bd5d4044553a75899ac170080f3e19ec2e574953b5c527d1e
We reuse the electrode files and explicit cortical gray matter label set. We verify all 257 electrode files against the reported dataset releases.
- usesThe true pairing had the largest cortical connectivity score across two movies in ten ds006192 participants after movie mean removal sci:sha256:d37b2419915defe483b7634a2855ce4503d3e0c5f5f7c8c95a84c3ca17f52e5e
We reuse the ten-person PAFIN source archive, including signals, labels, quality data, processing methods and source hashes.
- Hippocampal 2–13 Hz peaks were slower, mainly from 2–3 Hz peaks, in 79 RAM SEEG patients sci:sha256:ed1d62050f8a22f8afc1fde1dcf384b5649e365952b388b5b4aff45cb2320855
This prior analysis found slow hippocampal peaks in the overlapping RAM cohort. It gives context for band dependence and is not an independent replication.
- usesdoi:10.18112/openneuro.ds004789.v3.1.0
Public CC0 RAM FR1 source data and metadata.
- usesdoi:10.18112/openneuro.ds004809.v2.2.0
Public CC0 RAM catFR1 source data and metadata.
- usesdoi:10.18112/openneuro.ds006192.v1.0.0
Public CC0 PAFIN XCP-D source data and metadata, pinned to Git commit 782809420f256486cc2a749594f03b25226cae29.
- doi:10.52294/001c.151820
PAFIN study design, participant cohort, acquisition and source processing.
- doi:10.7554/eLife.61277
Prior electrical knee time scale work motivates an explicit regional transfer test.
- doi:10.1523/JNEUROSCI.1941-22.2023
Prior electrical temporal-limbic hierarchy evidence provides context for the measured SEEG contrast.
- doi:10.1073/pnas.2003383117
Prior fMRI work reports regional time scale gradients and more high-frequency hippocampal power than cortical power, with signal-to-noise limits.
Cited by
4 publicationsPublic catalog entries on Sciscape.
- usesHippocampal upper spectral quantiles showed no clear shared increase in 30 SEEG patients and ten fMRI participants at fixed bands
We reuse its verified spectra, labels and fMRI time series, and test whether its opposite median-frequency signs can coexist with a shared upper-tail order.
- usesCortical band median frequency rose with height in FR1 SEEG and fell in HCP resting fMRI after position controls
Verified source package supplied RAM spectra, electrode labels, and PAFIN signals. Its failed hippocampal transfer motivated a cortex-only test.
- usesMean band maps agreed more between files than band differences after distance and node controls in 36 SEEG patients and 10 fMRI participants
We reuse its preserved PAFIN source files and processing provenance. Its failed regional spectral transfer informed our choice of a measurement-level prediction.
- usesHippocampal upper spectral quantiles showed no clear shared increase in 30 SEEG patients and ten fMRI participants at fixed bands
We reuse its verified spectra, labels and fMRI time series, and test whether its opposite median-frequency signs can coexist with a shared upper-tail order.