The 95% interval included zero for the Fz versus 19-channel mean change in the CLN3 versus volunteer theta-to-alpha contrast using 80 seconds per person in 95 ds008896 records

We tested posterior theta-to-alpha power in 32 CLN3 and 63 healthy-volunteer EEG records from OpenNeuro ds008896 version 1.0.1. The primary test used the first 20 stored four-second epochs per person. We compared Fz with the mean of the same 19 scalp channels. Theta used [4,8) Hz and alpha used [8,13) Hz. The CLN3 minus volunteer log10 contrast was 0.194 with the mean reference and 0.167 with Fz. The paired contrast change was -0.027, with a 95% person bootstrap interval from -0.062 to 0.008. The interval included zero in all five planned checks. This does not establish a contrast change or reference equivalence. Scores changed order in 367 of 4465 person pairs. A shift of the band boundary to 7 Hz gave smaller group contrasts. The public data lack ages and clinical covariates, so these contrasts are unadjusted. The package contains spectra and real band matrices for all 5558 stored epochs, source metadata, locked retrieval recipes, code, results, and instructions. Separate signal and statistic checks passed for all 95 records. A fresh download and full rebuild gave identical hashes for 104 files, also in a clean Python environment.

EEG · reference sensitivity · theta-to-alpha power · CLN3 disease · spectral analysis · bootstrap interval · OpenNeuro