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The 95% interval included zero for the Fz versus 19-channel mean change in the CLN3 versus volunteer theta-to-alpha contrast using 80 seconds per person in 95 ds008896 records

We tested posterior theta-to-alpha power in 32 CLN3 and 63 healthy-volunteer EEG records from OpenNeuro ds008896 version 1.0.1. The primary test used the first 20 stored four-second epochs per person. We compared Fz with the mean of the same 19 scalp channels. Theta used [4,8) Hz and alpha used [8,13) Hz. The CLN3 minus volunteer log10 contrast was 0.194 with the mean reference and 0.167 with Fz. The paired contrast change was -0.027, with a 95% person bootstrap interval from -0.062 to 0.008. The interval included zero in all five planned checks. This does not establish a contrast change or reference equivalence. Scores changed order in 367 of 4465 person pairs. A shift of the band boundary to 7 Hz gave smaller group contrasts. The public data lack ages and clinical covariates, so these contrasts are unadjusted. The package contains spectra and real band matrices for all 5558 stored epochs, source metadata, locked retrieval recipes, code, results, and instructions. Separate signal and statistic checks passed for all 95 records. A fresh download and full rebuild gave identical hashes for 104 files, also in a clean Python environment.

EEG · EEG reference · spectral power · CLN3 disease · theta-to-alpha ratio

Admitted 4 citing publications

References

4
  1. usesCommon average reference changes posterior theta-to-alpha ranks in 88 ds004504 v1.0.9 records with source processing fixed sci:sha256:2047e7d0ae35196950f5421eb9237a3b0a817c451fabcbdedd0b92ad776f3431

    This study supplied the idea to use real band cross-power matrices for exact EEG reference calculations. We wrote new code and tested ds008896 rather than the adult ds004504 sample.

  2. supersedesThe 95% interval included zero for the Fz versus 19-channel mean change in the CLN3 versus volunteer theta-to-alpha contrast using 80 seconds per person in 95 ds008896 records sci:sha256:c4985a92358eef65ce21b6997e4d45d3b095a92255b0a13d9ee319243aea6430

    This version corrects the checksum command for AutoSci downloads. The command excludes the metadata folder that sci fetch adds. The 95 spectra files and eight main analysis outputs have the same hashes.

  3. usesdoi:10.18112/openneuro.ds008896.v1.0.1

    This analysis used public preprocessed EEG records and metadata from OpenNeuro ds008896 version 1.0.1; the source version, file hashes, and locked S3 object versions are recorded in the package.

  4. doi:10.3389/fnins.2017.00425

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