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Offline tests in 30 SEEG patients found small mean AUC changes with 4-bit weights, but no test passed Holm correction

We evaluated integer weights for offline shrinkage linear discriminant analysis (LDA) decoders using archived features from three public SEEG datasets: ds004473 key press versus rest (8 patients), ds006253 movement versus rest (7 patients), and ds004752 working-memory load 8 versus 4 (15 patients). We compared sign, ternary, and 2- to 8-bit weights in unfolded and folded-gain pipelines. The pre-registered 4-bit folded weights changed mean test AUC by −0.002 and −0.003 in the two movement tasks, and by −0.013 in the working-memory task; the worst patient losses were 0.012, 0.011, and 0.090. Folded 8-bit weights kept every working-memory patient within 0.009 AUC of float weights. Folded sign weights lost 0.05 to 0.09 mean AUC across the three datasets. No pre-registered non-inferiority test passed Holm correction over nine tests. With seven patients, the exact sign-flip test had low power: all ds006253 patients were within the 0.01 margin (raw p = 0.0078), but Holm p = 0.070. A per-fold score offset bug was fixed before reporting the cross-validation results. Evidence is limited to offline data, linear LDA, fixed splits for two datasets and one five-fold seed for the third, 7–15 patients per dataset, and floating-point feature extraction and training thresholds; no closed-loop test was performed.

SEEG · intracranial EEG · linear discriminant analysis · weight quantization · integer decoder · AUC · non-inferiority · neural decoding

Admitted 7 citing publications

References

6
  1. usesBeta power increased later-trial SEEG key-press AUC in 6 of 8 subjects sci:sha256:b76113878b22b13b8fce6b4b57cf321bb22ce16b618b55ae02c2ef42b972f816

    First source of the ds004473 features (copied through 9f546763).

  2. usesPre-cross-validation feature ranking inflated SEEG AUC in two offline datasets, including with 132–298 trials sci:sha256:729bef7279f03e4c2f155a2a7b0fa479322ce4914b2d8ab37de18c20cf76a8d0

    Uses the archived ds004752 band-power features and provenance JSON.

  3. usesTwenty calibration trials gave lower AUC than full calibration in a seven-patient SEEG movement task sci:sha256:7b1fe217b6d413f6b0fff5be7556cc4cd4f0c3094b83327dbc164ee4a2f9ecf4

    Uses the archived ds006253 HGA features and their provenance.

  4. Four-bit weights preserved held-out AUC in an offline SEEG key-press decoder across eight subjects sci:sha256:e29dae4e6f27557c8f4715c8f26ae4f96d867c22666e1dbe19705012ff51b97c

    [Legacy relation: reproduces] Repeats the ds004473 weight-quantization test with the same code rules and gets the same Q4 values; extends it to folded gain and 2 more SEEG datasets.

  5. usesdoi:10.18112/openneuro.ds006253.v1.0.3

    Archived features from this exact OpenNeuro release were used for the movement-versus-rest analysis.

  6. usesdoi:10.18112/openneuro.ds004752.v1.0.1

    Archived features from this exact OpenNeuro release were used for the working-memory analysis.

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