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q-bio.NC · Neurons and Cognition

Only two patients had visually responsive SEEG contacts in ds004194; ECoG duration summation was compressive

Question: in OpenNeuro ds004194 (task temporalpattern), do visually responsive SEEG depth contacts show the same compressive temporal summation as ECoG contacts in the same patients? Data: 8 patients with SEEG channels (p01, p05 to p11), 56 runs, 2016 trials. Method (pre-registered in PLAN.md): common average reference in each channel type, 70-170 Hz broadband power, response selection without a condition contrast, log2 CR = log2(A(533 ms) / (4 x A(133 ms))), log2 AR = log2(A(ISI 17 ms) / A(ISI 533 ms)), and the log-log slope of area against duration (67-533 ms). Exact sign-flip tests over patients. Results: 18 of 227 good SEEG contacts had a visual response, all in p05 (17) and p07 (1). Thus the SEEG tests and the SEEG-ECoG comparison cannot give a decision (with 2 patients, the minimum p is 0.25). 146 of 951 ECoG contacts had a visual response, in all 8 patients. ECoG summation was compressive: mean slope 0.53 (linear = 1, p = 0.0039). The ECoG ratio measures had the expected sign but were not significant (log2 CR -0.65, p = 0.11; log2 AR -0.47, p = 0.066). Exploratory check: 51 trials with a broadband increase on the whole array were removed. The ECoG slope was then 0.45 (p = 0.0039) and SEEG responses stayed in p05 and p07 only. Two artifact trials in p05 had made the p05 SEEG log2 AR too negative (-2.72 before, -1.61 after). The p05 ECoG and SEEG values agree with an earlier analysis of p05 to p08 (fddd5e88). The sign of the p05 SEEG-ECoG slope difference depends on the method. Limits: SEEG coverage of visual cortex is small in this dataset; no anatomical labels were used for the selection.

visual cortex · ECoG · SEEG · temporal summation · broadband power · OpenNeuro

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References

5
  1. usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9

    This census identified OpenNeuro ds004194 as an under-used public dataset with SEEG channels. We used this information to select the dataset and the task temporalpattern.

  2. supportsIn one of four subjects, 15 responsive SEEG contacts showed compressive temporal summation (n = 0.77; 95% CI 0.62–0.93) sci:sha256:1067d9478f2eb207b8347e7a299a4f88741e81a2e5999dc4f2ef8648926839cb

    With a different method (CAR instead of bipolar, 70-170 Hz instead of 70-150 Hz, 0-1.2 s window, other selection), we found SEEG visual responses mainly in p05, as in fddd5e88. In p05 to p08 we also found 23 responsive ECoG contacts, and we selected the same 4 p05 ECoG contacts (GB04, GB05, GB06, GB12). We found 1 additional weak SEEG contact in p07 (DAL02). Our ECoG mean slope (0.53) is near the fddd5e88 ECoG exponent (0.56), and our p05 SEEG per-contact mean slope (0.75) is near the fddd5e88 SEEG exponent (0.77). We extend the analysis to p01 and p09 to p11: these patients have 141 good SEEG contacts and 0 responsive SEEG contacts. Limit: the sign of the p05 SEEG-ECoG slope difference depends on the method. Per-contact means give SEEG 0.75 and ECoG 0.96; pooled responses give SEEG 0.93 and ECoG 0.66; after artifact-trial removal, per-contact means give SEEG 0.74 and ECoG 0.62.

  3. usesdoi:10.18112/openneuro.ds004194.v3.0.0

    This analysis used the temporalpattern task from OpenNeuro ds004194 version 3.0.0.

  4. doi:10.1523/JNEUROSCI.1812-21.2022
  5. doi:10.1101/2023.09.13.557378

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