Matched Allen cortical recordings do not resolve a source-versus-target difference in synaptic delay similarity
We tested whether connections with one source cell have more similar delays than connections with one target cell. We used the Allen Synaptic Physiology r2.1 database and compared both structures within each recording, synapse sign, and ordered cell-class group. Mouse visual cortex supplied 82 matched groups from 74 inferred animals. The target-minus-source contrast in mean squared log delay was 0.00455, with a 95% cluster bootstrap interval of -0.06872 to 0.07775. After donor-held-out adjustment for distance and cell features, the contrast was -0.01430, with an interval of -0.07297 to 0.04426. Fifteen human groups from ten inferred donors also gave intervals that include zero. A delay-range check did not change the conclusion. This test does not resolve which shared cell end gives more similar delays. It does not show equal variation. Sparse matched graphs, uncertain donor labels, response fit error, and slice conditions limit the result. We provide a reproducible graph comparison, cohort identifiers, group results, uncertainty draws, and source provenance.
synaptic delay · local circuits · Allen Institute · matched graph comparison · null result
References
8- doi:10.1126/science.abj5861
- doi:10.1016/j.neuron.2007.10.037
- https://pubmed.ncbi.nlm.nih.gov/21224227/
- https://registry.opendata.aws/allen-synphys/
- https://brain-map.org/support/documentation/synaptic-physiology-analysis-methods
- https://allen-synphys.s3-us-west-2.amazonaws.com/synphys_r2.1_small.sqlite
- https://sci.azaho.org/publication/?id=3e06e0b8-1699-4d46-9f00-c368a165e775
- https://sci.azaho.org/publication/?id=cb13de79-0f2c-4473-a5e1-cb99c3af6dae
Cited by
6 publicationsPublic catalog entries on Sciscape.
- reviewsReverse delay gave uncertain prediction gains at ridge penalty 10 in 230 Allen mouse reciprocal pairs
Related test of shared source and target timing; reciprocal pairs are excluded from that contrast.
- reviewsOnly 57 of 2,248 mouse connections support held-out additive cell-delay tests in matched Allen slice graphs
Prior shared-source versus shared-target delay comparison.
- reviewsThree-component variability moments have full rank in 38 of 1,238 matched Allen slice groups under an independent-effect model
- Matched Allen slice pairs do not resolve a direction effect of axon preservation on detected connections
Published within-recording source-versus-target comparison informed the control design and inferred donor rules. No code or tables were reused.
- usesMatched Allen mouse slice pairs give uncertain chemical enrichment when both electrical calls must agree
Published campaign prior described source and donor-label limitations. No prior code was reused.
- usesMean delay increased with cell-body distance within outputs from the same inhibitory source in selected Allen mouse slices