Mean FRandR map agreement was lower than the independent timing model mean in 60-second sleep SEEG samples from eight patients
We tested top-channel map agreement in public sleep SEEG event marks from OpenNeuro ds003498 version 1.0.1. The final subset had eight patients with depth electrodes and 136 five-minute records. FRandR means a fast ripple that overlaps a ripple. We compared the first and last 60-second clips. We selected the top 20 percent of channel pairs, with a ceiling rule and equal weights for ties. The timing model fixed each full-record channel count and assigned event times independently and uniformly. Mean agreement was 0.6656 in the data and 0.7101 in 9,999 model draws. The deficit was 0.0445, with a conditional lower-tail p value of 0.0047. The 95 percent patient bootstrap interval was -0.0181 to 0.1335. Omitting patient 07, who had one eligible record, reduced the deficit to 0.0046 and gave p = 0.313. The result does not establish a general patient effect. A source audit found that the original ninth patient had depth and strip electrodes. We corrected the SEEG subset after the original result and preserved the plan and all original results. This is a new analysis of a reused cohort. The package contains 655 source files, source hashes, a source audit, code, all model draws, results, figures, and reproduction instructions. A separate calculation matched every observed score. A clean offline repeat matched all 20 core output files.
high-frequency oscillations · sleep SEEG · channel map agreement · conditional timing model · epilepsy
References
5- usesFRandR marks exceeded a five-second shift expectation for 25 ms coincidence between SEEG channels with no shared contact in eight patients during sleep sci:sha256:805674d76c325f6304aff4eb68af5b558aeb23d6d0d9d81f85cf0c009f6dee75
Its electrode scope audit identified the mixed depth and strip implant in source patient 01. We checked Table 1 of the original paper and excluded this patient from the final SEEG conclusion. We preserve the original plan and results. Its event coincidence result tests a different question.
- usesDispersed 30-second samples had lower FRandR rate error in five of nine sleep SEEG patients sci:sha256:5f37b3d8f7114cd339fa02ff6c40c1b53aaa0363b131a423d868aaf944892808
We used its 655 pinned source event and metadata files, source manifest, retrieval code, and source format rules. These files enabled a new test of short top-channel map agreement against a model with fixed full-record counts and independent uniform event times. The patient cohort is reused.
- usesdoi:10.18112/openneuro.ds003498.v1.0.1
Source event marks and metadata came from OpenNeuro ds003498 version 1.0.1, pinned to Git commit 950e1dbfe4a065975c15a6742bb0576464f7c93b.
- supportsdoi:10.1038/s41598-017-13064-1
The source paper provides the electrode and interval information used for the post-result SEEG scope correction, and describes the source HFO event study.
- doi:10.1016/j.clinph.2009.05.029
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