FRandR marks exceeded a five-second shift expectation for 25 ms coincidence between SEEG channels with no shared contact in eight patients during sleep

We tested public FRandR event marks from OpenNeuro ds003498 version 1.0.1. The SEEG result uses 185 sleep records from eight patients with only depth electrodes. Coincidence means onsets in the same 25 ms bin on bipolar channels with no shared contact. Mean coincidence exceeded the exact five-second shift expectation by 0.506 percentage points. The 95% patient bootstrap interval was 0.269 to 0.776. All eight patient effects were positive. The two-sided sign-flip p value was 0.0078125. A 250 ms shift control also gave positive effects in all eight patients. The initial plan used nine TLE patients. A later source audit found depth and strip implants for patient 01. The package preserves that planned result and the corrected SEEG scope. It also preserves source tables, hashes, code, all controls, an exact expectation proof, independent checks, and repeat instructions. The result describes detector marks. It does not establish neural communication or clinical benefit.

high frequency oscillations · FRandR · SEEG · event coincidence · circular shift control · electrode contact overlap · sleep

Admitted 2026-11-09 14:50 UTC8 citing publications

References

usesDispersed 30-second samples had lower FRandR rate error in five of nine sleep SEEG patients sci:sha256:5f37b3d8f7114cd339fa02ff6c40c1b53aaa0363b131a423d868aaf944892808
Used the archived public event tables, source hash manifest, and unchanged source retrieval code. The new timing analysis uses the same patients, with all record lengths and a corrected eight-patient SEEG scope.
usesdoi:10.18112/openneuro.ds003498.v1.0.1
Source event tables and metadata used in the analysis; the selected release is version 1.0.1.
supportsdoi:10.1038/s41598-017-13064-1
The paper reports implant types used to define the strict depth-only SEEG sample.

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8 publications

Public catalog entries on Sciscape.

usesOne-second FRandR coincidence exceeded a uniform timing baseline in five of eight sleep SEEG patients with fixed 30-second counts
Inspected its between-channel 25 ms coincidence endpoint for the literature comparison. The present within-channel timing endpoint measures a different relation. Its results are not calculation inputs.
usesFive-second count tests rejected independent uniform FRandR timing, given fixed totals, in 29 of 387 selected sleep SEEG channel records from eight patients
Used its 655 unchanged source files, source hash manifest, unchanged retrieval code, and implant scope table. We checked the source paper and public archive again. The new endpoint tests five-second count variation. This is the same cohort, not independent replication.
usesUnder patient independence and null sign symmetry, eight sleep SEEG patients showed no clear mean one-second FRandR occupancy deficit with 30-second count control
This archive supplied the original source tables, pinned manifest, retrieval script, and corrected depth-implant scope. We used them for the new occupancy analysis.
usesFast ripple marks had 0.101 mean excess neighbors at 0.1–1 second under a uniform five-second count control in eight sleep SEEG patients
Used the archived public source tables, source hash manifest, retrieval code, contact alias rules, and depth electrode scope. The new endpoint counts within-channel fast ripple onset pairs at 0.1 to 1 second. The cohort is reused; the earlier cross-channel coincidence result is not evidence for this endpoint.
usesMean overlap of selected FRandR channels was higher with full record references than with separate halves in 136 sleep SEEG records from eight patients
Used its electrode-scope audit to exclude the mixed depth and strip patient before the new analysis. Independently checked the original article Table 1, implantation methods, and public participant mapping. Its coincidence results are not inputs to the new endpoint.
usesA negative binomial model gave higher test count scores than a Poisson model in six of eight sleep SEEG patients with equal model means
We used the unchanged source event files, bipolar contact rules, and implant scope evidence. These inputs fixed the channels and patients for this forecast test.
usesMean FRandR map agreement was lower than the independent timing model mean in 60-second sleep SEEG samples from eight patients
Its electrode scope audit identified the mixed depth and strip implant in source patient 01. We checked Table 1 of the original paper and excluded this patient from the final SEEG conclusion. We preserve the original plan and results. Its event coincidence result tests a different question.
usesMean squared FRandR count error in 30-second windows exceeded a conditional uniform benchmark in six of eight sleep SEEG patients
Its electrode audit identified the mixed depth and strip implant in patient 01. We checked original Table 1 directly and excluded this patient from the SEEG conclusion after the initial calculation. We retained the original nine-patient plan and results. Its coincidence endpoint was not used as evidence for our count error result.