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q-bio.NC · Neurons and Cognition

One-second FRandR coincidence exceeded a uniform timing baseline in five of eight sleep SEEG patients with fixed 30-second counts

We measured supplied fast ripple and ripple marks, called FRandR, in public stereoelectroencephalography (SEEG) sleep data. We used 185 recordings from eight patients with depth electrodes only. We counted onset pairs on each bipolar channel in one-second bins. The reference fixed each channel count in each 30-second block. It assumed independent, uniform timing within that block. The mean coincidence ratio was 1.261 with equal patient weights. Five patient ratios were above 1; three were below 1. The 95% patient bootstrap interval was 0.977 to 1.542. These data do not establish a common increase across patients. A source audit excluded a mixed depth-and-strip patient after the first calculation. The corrected analysis is exploratory. The package preserves the initial plan and all nine-patient results. It contains source event tables, source hashes, code, patient and channel results, equations, figures, and repeat instructions. Independent counts matched all 185 arrays and all 41,013 channel/block totals. A fresh download matched all 655 source file hashes. Fresh runs reproduced both cohorts. The result describes detector marks and does not prove neural coupling or clinical benefit.

high frequency oscillations · stereoelectroencephalography · sleep · event timing · coincidence ratio · conditional reference model

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References

6
  1. usesFRandR counts in 5-second bins had a mean correlation of 0.069 between named shafts in nine sleep SEEG patients after removal of 30-second means sci:sha256:dc09e3b9ab20f503a8309120cd24d84716daf5530d0066b67d921cd877669be9

    Reused 655 source event and metadata files, their provenance manifest, and source retrieval code. Adapted source checks and contact aliases to construct half-second counts. Parent correlation results and count arrays are not analysis inputs.

  2. usesCombined HFO marks showed excess 20 ms coincidence between shafts during sleep SEEG in eight patients under a conditional rotation model sci:sha256:324234ceb7d48b2137c5f350179c40f4d5eecedf32837cc9218b102f7905c2df

    Inspected its between-shaft 20 ms coincidence endpoint for the literature comparison. The present endpoint counts onset pairs on the same bipolar channel in one-second bins with fixed 30-second totals. Its results are not calculation inputs.

  3. usesFRandR marks exceeded a five-second shift expectation for 25 ms coincidence between SEEG channels with no shared contact in eight patients during sleep sci:sha256:805674d76c325f6304aff4eb68af5b558aeb23d6d0d9d81f85cf0c009f6dee75

    Inspected its between-channel 25 ms coincidence endpoint for the literature comparison. The present within-channel timing endpoint measures a different relation. Its results are not calculation inputs.

  4. usesDispersed 30-second samples had lower FRandR rate error in five of nine sleep SEEG patients sci:sha256:5f37b3d8f7114cd339fa02ff6c40c1b53aaa0363b131a423d868aaf944892808

    The short-sample event-rate study informed the question about local event timing. It is also the upstream source of the retrieved manifest and retrieval code. We preserve its source credit.

  5. usesdoi:10.18112/openneuro.ds003498.v1.0.1

    This is the recorded version-specific DOI for the OpenNeuro ds003498 event and metadata files used in the analysis.

  6. supportsdoi:10.1038/s41598-017-13064-1

    The cited paper supplies the FRandR event definitions and the implant-type evidence used to set the reported cohort scope.

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