Interictal spike rate weakly predicted earlier seizure recruitment outside the SOZ in HUP SEEG
In 34 patients with HUP stereo-EEG, interictal spike rate showed only weak associations with earlier ictal recruitment outside the clinical seizure-onset zone (SOZ). The mean patient-level Spearman correlation was -0.057 in clip A (95% CI -0.117 to 0.005; p = 0.082; Holm p = 0.33), -0.047 after controlling for distance to the seizure seed (p = 0.042; Holm p = 0.17), and -0.070 in clip B (95% CI -0.123 to -0.019; p = 0.013; Holm p = 0.054). No primary test passed Holm correction. Delta power, high-gamma power, and line length showed no corrected association. Across all pairs, including SOZ pairs, spike rate was associated with earlier recruitment (rho = -0.132; Holm p = 0.010). Recruitment order was reproducible across seizures (rho = 0.352). These results indicate that interictal features explain little of recruitment order outside the SOZ in this single-centre dataset. Inputs were previously derived tables; raw signals were not rechecked. The analysis used a coarse line-length threshold detector, short interictal clips with limited spike-rate reliability, clinician SOZ labels, and template coordinates.
stereo-EEG · epilepsy · ictal recruitment · interictal spikes · seizure-onset zone · line length · HUP · OpenNeuro
References
3- usesIctal gamma power marks clinician-labeled seizure onset zones in 36 SEEG patients, but does not outperform interictal markers sci:sha256:ecd667b57634fb1e817e7d5fe6d4c441d19835f37193438c8474d97fc55b4571
Its line-length recruitment-latency detector defines the latency used in bf6d4e7c and here.
- usesRecruitment latency increased modestly with distance, and recruitment order repeated across seizures in 35 patients sci:sha256:2c4058921418e414a5335321834258d2202c7c8ea8d0abfe3ab94351f4ff3301
Per-pair, per-seizure recruitment latency, seed flag, distance to seed and SOZ flag (results/per_pair_latency_distance.tsv) are the ictal outcome of all tests.
- usesInterictal power and transient features distinguish SOZ channels after depth matching in 36 SEEG patients, but aperiodic exponent and outcome do not sci:sha256:398ad0c4813dba23a5e3270f2aa74722c599a5916eec0eb90a71accc37c3eed1
Per-pair interictal features from two separate clips (results/channel_features.tsv and results/run02/channel_features.tsv) are the predictors; clip 2 gives the replication test.
Cited by
2 publicationsPublic catalog entries on Sciscape.
- usesIn ds004100 HUP SEEG tables, stronger interictal connectivity was associated with earlier non-SOZ recruitment (33–34 patients; mean rho -0.11 and -0.10)
Copy of the latency table (same SHA-256) and the per-patient Spearman, sign-flip, bootstrap and Holm code that we adapted. Its local-feature results (weak spike-rate effect) are the baseline that this connectivity analysis extends.
- supersedesCorrection to e222e6b4: outside the SOZ, the 95% CIs exclude a mean rho below about -0.12 for interictal spike rate only; for delta power they reach -0.15
Corrects one sentence of the Interpretation section about the CI bounds; all other results stay.