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Under person t tests, mean voice transfer was above chance in six SEEG patients and two fMRI groups; the test for all nine clips failed

We tested whether a speech/song-trained neural reader ranks excluded nonspeech human voices above excluded source nonvoice sounds. Separate public studies supplied high-gamma SEEG and BOLD fMRI. Two patients and four MRI adults supplied development. A local code lock preceded new endpoints in six patients, 16 B2021 adults and eight NH2015 adults. Each reader used scales from training data. We removed the spatial mean and set response length to one. We subtracted the pre-event mean from electrical responses. Mean transfer AUCs were 0.63385, 0.82835 and 0.81648. Their 95% person Student limits were [0.57936,0.68834], [0.80462,0.85209] and [0.79383,0.83913]. All 30 person means exceeded 0.5. A shared mean test also required held-speech validation and an electrical gain over a pre-event reader. It passed two-claim Holm correction, p=0.001533. A stronger fixed test required positive mean AUC for every one of nine voice clips in each study. It failed, p=0.789458. The weakest electrical clip had mean 0.45681 [0.33010,0.58353]; its name is unavailable. The scream clip was uncertain in the added MRI study. The minimum clip mean equals the worst AUC over offline mixtures of fixed voice score distributions against the fixed background. This elementary result gives no guarantee for new voices or different background weights. A small-site control left electrical and added-MRI two-sided intervals across chance. Independent arithmetic checked all 30 test people. Source hashes and an offline audit passed. These are new endpoints in reused studies, with one added MRI acquisition and no new electrical study. Small clinical samples, source screens, common task schedules, missing common acoustics, different cohorts, unequal spatial sampling and measurement filters limit scope. An exact single-factor example gave AUC 1 under the same method. No common circuit or causal effect was shown. Code, source pins and terms, all failures, figures and repeat steps are supplied.

human neuroscience · SEEG · fMRI · voice perception · cross-context transfer · sound mixtures · subject-level inference · negative result · reproducible benchmark

Admitted 2 citing publications

References

13
  1. doi:10.1038/35002078
  2. usesdoi:10.1371/journal.pbio.3001675

    Source human SEEG high-gamma data and study methods.

  3. usesdoi:10.5281/zenodo.6544488

    Rupp public data v1.1; exact author Git bytes and complete SHA-256 pins are preserved.

  4. usesdoi:10.1152/jn.00588.2020

    Independent human B2021 fMRI source cohort.

  5. usesdoi:10.1016/j.neuron.2015.11.035

    Added NH2015 fMRI study and natural sound source.

  6. usesdoi:10.1371/journal.pbio.3002366

    Public author archive supplies B2021 response estimates and source processing details.

  7. usesAtlas forecasts lowered error for fixed sounds in SEEG and fMRI; an added SEEG baseline control gave no clear gain sci:sha256:ba35a09a961a79cec0ece21017c0c36cfb20e42ad6e878f5194308bce4a36d4d

    MIT fetcher and source readers, exact source pins, inherited attribution, and reported sensitivity to electrical baseline subtraction.

  8. supportsFixed speech readers kept human preference in 20 iEEG patients and 16 fMRI adults; animal transfer was not shared sci:sha256:4b646291a39bd00f123dff1c78a1c0e0f45e95899b8a8a3e18ec0e969526d498

    Known prior speech-to-nonspeech voice transfer motivates a stronger fixed-clip test; it is not independent evidence for this endpoint.

  9. supportsFor fixed sounds, speech readers kept mean voice AUC above 0.5 after at least half of non-vocal variation was removed in iEEG and fMRI sci:sha256:8e50d8351afbb20b98ab50e2b9955b722a55eee88d75f94c6d95f91c7f843e97

    Prior response-space transfer test motivates limits on average voice AUC.

  10. supportsSpeech and song axes gave positive mean repeat scores for nine voice clips in SEEG and two fMRI cohorts sci:sha256:6720e49a50bda02902607508181e2616c7f5e48b21bceee56a2d3fcdc618bdae

    Earlier speech/song-axis analysis in the same public sources tested within-voice repeat structure, rather than the present all-clip ranking claim.

  11. doi:10.1016/j.cub.2015.06.043
  12. doi:10.7554/eLife.82566
  13. doi:10.1093/cercor/bhac128

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