The ds004080 derivative has no depth-contact N1 detections; surface N1 latency decreases with age
An audit of the OpenNeuro ds004080 v1.2.4 CCEP derivative found no N1 detections among 232 depth-contact recording rows or 101 depth-depth stimulation pairs from 24 patients. The derivative therefore cannot test depth-contact latency versus age; the planned depth tests had zero qualifying patients. In a reproduction using the authors’ detector and native distances, 39,748 surface responses from 73 patients aged 4–51 showed lower median N1 latency with age (Spearman ρ = −0.370, permutation p = 0.0015; 20,000 permutations). The association remained after pooled distance adjustment (ρ = −0.375, p = 0.0010). Median distance was not associated with age (ρ = −0.059, p = 0.63). The surface result is not independent of the source paper. The depth question remains unresolved without new N1 detection on raw SEEG recordings. All patients had epilepsy and the age comparison was cross-sectional.
CCEP · N1 latency · SEEG · ECoG · depth contacts · age · distance adjustment · OpenNeuro ds004080
References
2- usesdoi:10.18112/openneuro.ds004080.v1.2.4
The analyzed CCEP derivative, participant table, and electrode metadata are from this recorded dataset release.
- doi:10.1038/s41593-023-01272-0
Cited by
3 publicationsPublic catalog entries on Sciscape.
- usesCommon-reference removal does not restore the surface CCEP N1 age-latency control in sampled ds004080 epochs
Its surface age-latency rho (-0.37) from the authors' N1 derivatives is the reference value for our positive control.
- usesExpert-checked CCEP N1 latency increased with Euclidean distance in all 8 SEEG patients; an age effect was not shown in 13 patients
That audit showed that ds004080 has no depth N1 detections, so a SEEG latency test was not possible there. This package does the SEEG latency-distance test in a different dataset (ds005448). The age test here (n = 13) does not show an effect, but its power is low. Thus it does not challenge the surface age effect in 73 patients of that package.
- usesSampled SEEG recordings did not show a surface-like age decrease in CCEP N1 latency
We use its depth audit for the list of 24 patients with depth contacts, and its copy of participants.tsv for the ages. Its surface age-latency rho (-0.37) is the reference value for our positive control.