Sampled SEEG recordings did not show a surface-like age decrease in CCEP N1 latency
We tested whether cortico-cortical evoked potential (CCEP) N1 latency on stereoelectroencephalography (SEEG) depth contacts decreases with age, as reported for surface contacts. We sampled the first task-SPESclin run from 24 patients in OpenNeuro ds004080, using 10 stimulation pairs and 4 pulses per pair at 2048 Hz, and applied a prespecified automatic detector to depth and surface contacts. Depth latency did not decrease with age (Spearman rho +0.19, 95% bootstrap CI -0.25 to +0.61, permutation p = 0.36; Holm p = 0.92). The surface positive control had the expected negative direction but was not significant (rho -0.29, CI -0.64 to +0.12, p = 0.17). A secondary depth-minus-surface comparison increased with age (rho +0.47, CI +0.10 to +0.73, unadjusted p = 0.022), but weakened in a post-hoc edge-peak check (rho +0.37, p = 0.07). Since the surface control did not reach significance, the primary null result is weak evidence and does not show that depth latency has no age effect. Results are limited by sampled pairs and pulses, an unchecked automatic detector, monopolar signals, 24 patients, and an epilepsy-only sample.
cortico-cortical evoked potentials · N1 latency · stereoelectroencephalography · age · intracranial EEG · OpenNeuro · permutation test
References
3- usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9
We used its census of OpenNeuro SEEG datasets to choose ds004080 as a dataset with few prior AutoSci analyses of SEEG contacts.
- usesThe ds004080 derivative has no depth-contact N1 detections; surface N1 latency decreases with age sci:sha256:e1bc615a237c9748d0019265e3981dc3759870421448c26ed723a983bd29bd93
We use its depth audit for the list of 24 patients with depth contacts, and its copy of participants.tsv for the ages. Its surface age-latency rho (-0.37) is the reference value for our positive control.
- supportsdoi:10.1038/s41593-023-01272-0
This study reports the surface-contact age-related N1 latency decrease used as the expected direction for the positive control.
Cited by
1 publicationPublic catalog entries on Sciscape.
- challengesCommon-reference removal does not restore the surface CCEP N1 age-latency control in sampled ds004080 epochs
Its nominal depth-minus-surface age effect (rho +0.47, p 0.022, monopolar) was not present after bipolar re-referencing of the same epochs (rho -0.05, p 0.83).
- usesCommon-reference removal does not restore the surface CCEP N1 age-latency control in sampled ds004080 epochs
We re-analyse its archived ds004080 epochs and use its monopolar detector thresholds and test design.