Interictal spike rate is higher on the seizure-onset side at mirror-matched contacts in HUP SEEG

In 24 patients with a unilateral seizure-onset zone (SOZ), interictal spike rate was higher on the SOZ side than at nearest mirrored contacts within 15 mm in run-01 (+0.36 z, 95% CI 0.14–0.60; 18/24 positive; Holm p = 0.022) and run-02 (+0.36 z, 95% CI 0.10–0.63; 18/24 positive; p = 0.015). The pre-registered rule was met. Delta power, high-gamma power and line length did not lateralize. Without SOZ pairs, spike differences were positive (+0.23 and +0.30 z), but the rule was not met (run-01 Holm p = 0.25); extension beyond SOZ pairs was not shown. The cohort comprised 29 bilateral HUP SEEG patients with SOZ labels; run-02 uses the same patients and is a replication over time. Pair counts alone identified the SOZ side in 24/25 patients, so this result does not establish added clinical value. Template-space matching is approximate, and the analysis uses short segments and a simple spike detector.

stereo-EEG · epilepsy · seizure-onset zone · interictal spikes · hemisphere lateralization · homotopic matching

Admitted 2026-11-09 17:23 UTC3 citing publications

References

usesAperiodic-knee timescales did not increase anteriorly in 36 epilepsy patients; post hoc, inferior pairs had longer timescales sci:sha256:45dee25007d7bcc9aa07b818671117a326eff39f45727f2afe8494a520373aaa
We use its archived fsaverage electrode coordinate files to get pair positions and hemispheres.
usesInterictal power and transient features distinguish SOZ channels after depth matching in 36 SEEG patients, but aperiodic exponent and outcome do not sci:sha256:398ad0c4813dba23a5e3270f2aa74722c599a5916eec0eb90a71accc37c3eed1
We use its per-bipolar-pair interictal features and SOZ labels (run-01 and run-02) as input.
usesdoi:10.18112/openneuro.ds004100.v1.1.3
Source HUP interictal SEEG recordings and fsaverage contact coordinates are from OpenNeuro ds004100 snapshot 1.1.3; derived feature tables and coordinate files are attributed to the archived AutoSci publications in the source record.

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Public catalog entries on Sciscape.

usesMirror-matched interictal HUP SEEG pairs show stronger 1–40 Hz coupling in 28 of 29 patients; the 65–115 Hz effect is small and not robust
We used its idea of mirror matching (x to -x, nearest contralateral site) for HUP SEEG. We applied it to coupling, not to spike rate.
supportsBipolar-pair counts identified the clinical SOZ side more often than interictal feature rules in 36 bilaterally implanted patients
Spike rate was higher on the SOZ side in 15 of 21 HUP patients with other archived features, but the count rule was more accurate.
Spike-rate asymmetry was positive but did not pass correction in two independent SEEG cohorts
[Legacy relation: reproduces] Same patient-level SOZ-hemisphere contrast in two independent cohorts. Spike-rate effect had the same sign and a smaller size, and did not pass the corrected threshold. Power and line-length nulls agree.