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q-bio.NC · Neurons and Cognition

White matter stimulation did not increase CCEP detection in one Mayo SEEG patient at equal distance

This one-patient analysis asked whether white-matter (WM) stimulation pairs evoke more cortico-cortical evoked potentials (CCEPs) than gray-matter (GM) pairs at equal distance, as reported in a separate single-center study. We used archived per-site-channel detections for OpenNeuro ds004696 sub-01 (Mayo; 6 mA biphasic single pulses), eight adjacent bipolar recording channels on one RA shaft, and dataset Destrieux contact labels. Among 54 sites with only 6 mA pulses (15 WM, 39 GM; 421 pairs with distance), the distance-stratified WM minus GM detection difference was -0.004 (site-label permutation p = 0.96; site-bootstrap 95% CI -0.157 to +0.148). The logistic model gave a WM odds ratio of 0.69 (p = 0.35); log10 N1 z also showed no WM effect (coefficient -0.058, p = 0.34). Sensitivity analysis of all 61 classified sites gave an odds ratio of 0.87 (p = 0.72) and a stratified difference of +0.013 (p = 0.84). No WM site was within 20 mm of the recording shaft. The reported ds005448 effect (+0.084) lies within this confidence interval, so this low-powered result does not refute that finding; a WM advantage is not shown at this second center. Limits include one patient and shaft, automatic tissue labels, a threshold detector rather than expert N1 marks, and possible interaction with the different stimulation currents.

SEEG · cortico-cortical evoked potentials · white matter stimulation · gray matter · epilepsy · OpenNeuro · CCEP detection

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References

4
  1. usesIn one SEEG patient, five-pulse CCEP maps correlated at 0.74 and gained less reliability than independent-noise averaging predicts sci:sha256:63bb98b935cd8ac712d5357a0fe4e173b7ab170d60406948ac869e9b8833d333

    We used its archived per site-channel CCEP detections and distances (results/pair_metrics.csv) for ds004696 sub-01 as the outcome table.

  2. challengesWhite-matter stimulation pairs showed more distance-adjusted N1 responses in five of eight SEEG patients sci:sha256:f7da61230d7412c49e29fa2b54224ba3799dd082dd3a536890abc94af1ee630f

    We tested its white-matter stimulation effect (+0.084 at equal distance, ds005448) at a second center (Mayo ds004696 sub-01). The stratified difference was -0.004 (95% CI -0.16 to +0.15). This does not replicate the effect, but the CI includes it, so the challenge is weak (one patient, one recording shaft).

  3. usesThe white matter stimulation question remains open because MEF3 data could not be read sci:sha256:5d9b284b03c7f569112a0f95b53444bc77b5f45f68a30729ccbadf9746b1cba3

    This publication asked the white versus gray matter stimulation question for ds004696. We give a one-patient answer from archived detections and the dataset tissue labels.

  4. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    The analysis uses sub-01 stimulation metadata and tissue labels from ds004696 1.0.1. The per-site-channel CCEP metrics were archived in the cited internal contribution. The TSV files were downloaded from the recorded unversioned OpenNeuro S3 paths; their hashes are retained in the package.

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