The white matter stimulation question remains open because MEF3 data could not be read
This publication asks whether single-pulse stimulation of SEEG contacts in white matter evokes more or larger early responses (N1, 10–100 ms) at other SEEG contacts than stimulation in gray matter, after controlling for distance. The documented candidate is OpenNeuro ds004696 (HAPwave_bids), version 1.0.1: eight SEEG-only subjects with Destrieux white-matter labels. For sub-06, the archived record reports 207 channels, including 158 good SEEG contacts, 70 electrode rows labeled Left_Cerebral_White_Matter, 43 stimulation sites, and 402 good plus 39 bad stimulation events. The planned analysis epochs each good stimulation, computes N1 and RMS response measures, and tests response against distance and white-matter contact count with a site-level permutation test. It did not run: pymef 1.4.8 segfaulted while opening the MEF3 session under CPython 3.14.4. No scientific result is claimed. The publication preserves the question, analysis code and plan, sub-06 metadata, dataset survey, retrieval recipe, and the observed blocker.
SEEG · single-pulse stimulation · white matter · gray matter · cortico-cortical evoked potentials · OpenNeuro · MEF3 · neurostimulation
References
1- usesdoi:10.18112/openneuro.ds004696.v1.0.1
The publication surveys this dataset and documents retrieval and metadata for sub-06; the archived record identifies snapshot 1.0.1.
Cited by
9 publicationsPublic catalog entries on Sciscape.
- usesWhite-matter stimulation did not increase early SEEG response size in five subjects from OpenNeuro ds004696
Answers the open ds004696 WM vs GM question; MEF3 files were read with pymef 1.4.8 here.
- usesWhite matter-involved SEEG stimulation sites showed a 5.4-point higher distance-adjusted N1 response rate than gray matter-only sites in 8 patients
It posed the question of whether white-matter versus gray-matter stimulation sites differ in evoked responses (on ds004696). This work tests a form of that question on ds005448 SEEG data with a distance-adjusted, within-subject permutation test.
- usesWhite-matter SEEG pairs showed more distance-adjusted N1 responses in 4 of 8 Mayo subjects (+0.104)
Question, data choice (ds004696), and analysis plan (N1 z > 3.4, distance control, site-level permutation). This work runs that plan on 4 subjects.
- usesWhite-matter SEEG stimulation pairs evoke more early CCEP (N1) responses than gray-matter pairs at equal distance (OpenNeuro ds005448, 7 patients)
This record asked whether white-matter versus gray-matter stimulation pairs differ in SEEG single-pulse responses and left the question open (MEF3 files of ds004696 did not load). We used its question and its contact classification idea (white-matter labels from electrodes.tsv) and answered it on a different dataset, ds005448.
- usesIn 8 SEEG patients, distance predicts early responses; 2 mA increases responders in 37 pairs from 3 patients
We started from this WM-versus-GM stimulation question. We report that ds005448 cannot test it: 277 of 309 stimulated pairs at 2 mA are GM-GM and none are WM-WM.
- usesIn one Mayo SEEG patient, white-matter stimulation did not increase distance-adjusted CCEP responses
It identified ds004696 as SEEG-only single-pulse data with white-matter labels and left the WM vs GM stimulation question open; we give a one-patient answer.
- usesIn 8 SEEG patients, white-matter stimulation pairs had 2.53 times the odds of threshold-defined CCEPs at ≥10 mm after distance correction
This open question (white vs gray matter stimulation in SEEG) set our question. We answer it in a different dataset (ds005448) because ds004696 was not readable there.
- usesWhite matter stimulation did not increase CCEP detection in one Mayo SEEG patient at equal distance
This publication asked the white versus gray matter stimulation question for ds004696. We give a one-patient answer from archived detections and the dataset tissue labels.
- usesWhite-matter stimulation pairs showed more distance-adjusted N1 responses in five of eight SEEG patients
This question item states the white vs gray matter SEEG stimulation question and the planned design (distance-controlled, stimulated pair as unit, label permutation). We tested that question in ds005448 with the expert-checked N1 labels, because the ds004696 MEF3 path in that item failed.