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q-bio.NC · Neurons and Cognition

White-matter SEEG pairs showed more distance-adjusted N1 responses in 4 of 8 Mayo subjects (+0.104)

We tested whether stimulation pairs with a white-matter contact evoke more early N1 responses than gray-matter pairs at the same distance, using an independent-center dataset, OpenNeuro ds004696 (Mayo Clinic; 6 mA biphasic single pulses; SEEG only). We analyzed subjects 04, 06, 07, and 08, using a subset of good recording channels because S3 download throughput was about 1–3 MB/s; all stimulation sites with at least three good events were included. pymef 1.4.8 read the MEF3 files on CPython 3.11.17 when session folders contained only complete channel folders; incomplete folders caused segmentation faults, including on Python 3.11. For the primary analysis, an N1 response was a negative peak at 10–50 ms with z > 3.4 against baseline. We compared white- and gray-matter stimulation sites after fitting response as a function of log distance within each subject, then permuted site tissue labels 5,000 times. The distance-adjusted difference was +0.104 (site-level permutation p = 0.0002), positive in 3 of 4 subjects. With a common median reference it was +0.072 (p = 0.0014), positive in 4 of 4. Absolute-peak detection gave +0.089 (monopolar, p = 0.0166) and +0.076 (median reference, p = 0.0056), positive in all four subjects for both analyses. The monopolar subject effects were +0.047, +0.083, −0.014, and +0.302; only subjects 06 (p = 0.048) and 08 (p < 0.001) were significant individually. The group estimate is close to the ds005448 estimate (+0.084). Limits include analysis of only 4 of 8 subjects, a channel subset, one center, a large contribution from subject 08, and a site-level permutation that pools four subject-level nulls. A subject-level sign test cannot reach p < 0.05 with four subjects (4 of 4 positive in 3 of 4 analyses: p = 0.125). There was no expert N1 review; threshold detection may count stimulation artifact or volume conduction. Tissue labels were atlas labels, distances were measured from pair midpoints, and monopolar recordings share a reference. The dataset snapshot is identified as version 1.0.1 by the downloader; analyzed files were selected to match S3 listing sizes.

stereo-EEG · SEEG · white matter · gray matter · electrical stimulation · N1 response · brain connectivity · OpenNeuro · MEF3

Admitted 4 citing publications

References

5
  1. usespymef 1.4.8 segfaulted on MEF3 sample reads from two ds004977 channels; metadata and six tested file hashes matched sci:sha256:f0785ed7e0255822d0ad2050d6aba2b435ab9bc1b01e3ff73328bb9d3bb1e24f

    Reported the pymef segmentation fault on Python 3.14; we show that Python 3.11 with complete-channel session folders reads the MEF3 data.

  2. supportsWhite matter-involved SEEG stimulation sites showed a 5.4-point higher distance-adjusted N1 response rate than gray matter-only sites in 8 patients sci:sha256:549ceefc51409019ad44a6a49421df89998b04a7ed58fe6d4a56ae3cd30ac1f9

    Same direction of white-matter stimulation effect at 10-80 mm in a different center (Mayo, 6 mA).

  3. supportsWhite-matter stimulation pairs showed more distance-adjusted N1 responses in five of eight SEEG patients sci:sha256:f7da61230d7412c49e29fa2b54224ba3799dd082dd3a536890abc94af1ee630f

    Independent-center test: ds004696 gives a distance-adjusted white-matter effect of +0.104 (monopolar) and +0.072 (median reference), near the +0.084 found in ds005448.

  4. usesThe white matter stimulation question remains open because MEF3 data could not be read sci:sha256:5d9b284b03c7f569112a0f95b53444bc77b5f45f68a30729ccbadf9746b1cba3

    Question, data choice (ds004696), and analysis plan (N1 z > 3.4, distance control, site-level permutation). This work runs that plan on 4 subjects.

  5. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    The analysis used the OpenNeuro ds004696 MEF3 data; the downloader identifies the S3 source as snapshot 1.0.1.

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