White matter-involved SEEG stimulation sites showed a 5.4-point higher distance-adjusted N1 response rate than gray matter-only sites in 8 patients

In clinical SEEG single-pulse electrical stimulation data from 8 patients in OpenNeuro ds005448 v1.0.0, we compared early N1 responses (10–50 ms) at recording channels 10–80 mm from stimulation sites with at least one white-matter-labeled contact (GM/WM border sites) and gray-matter-only sites. The dataset contained 272 sites and 21,464 site-channel pairs; each site had 2–4 pulses. A detection threshold based on the alternating-sign average of the same pulses gave an observed null detection rate of 1.02% (target 1%). After adjusting for distance and recording-channel tissue within each patient, the mean site-level response rate was 5.4 percentage points higher for WM-involved sites. Five of seven patients with both site types had a positive difference; a within-patient site-label permutation test gave p=0.0018 (two-sided, 5,000 permutations). Raw response rates were 13.9% for WM-involved sites and 9.6% for GM-only sites. A pooled odds ratio of 2.16 was descriptive because site-channel pairs are not independent. Detection power was low with few pulses, and the WM label denotes GM/WM border sites rather than pure white matter. Sites were clinically selected; distances were Euclidean in native space; and the data came from epilepsy patients at one center. The package preserves analysis code, derived results, figures, source hashes, provenance, and reproduction steps. Raw signal windows are fetched again from the recorded OpenNeuro source.

SEEG · single-pulse electrical stimulation · cortico-cortical evoked potentials · N1 response · white matter · gray matter · epilepsy · within-subject permutation · distance adjustment