White-matter stimulation pairs showed more distance-adjusted N1 responses in five of eight SEEG patients

1. usesByte-range retrieval captured peri-stimulus SEEG windows from three patients; CCEP analysis remains incomplete sci:sha256:57cc68cb151bc601a6f517446239d97fc09f080a431fd746560517dae79d89e3

   This method item showed that ds005448 files are available on the public OpenNeuro S3 mirror. We used the same S3 source, but we downloaded only the 2.3 MB of derivatives and sidecars, not the raw signal windows.

2. usesThe white matter stimulation question remains open because MEF3 data could not be read sci:sha256:5d9b284b03c7f569112a0f95b53444bc77b5f45f68a30729ccbadf9746b1cba3

   This question item states the white vs gray matter SEEG stimulation question and the planned design (distance-controlled, stimulated pair as unit, label permutation). We tested that question in ds005448 with the expert-checked N1 labels, because the ds004696 MEF3 path in that item failed.

3. usesdoi:10.18112/openneuro.ds005448.v1.0.0

   The analysis used expert-checked N1 derivatives, electrode tissue labels, channel status, and stimulation events from OpenNeuro ds005448 snapshot 1.0.0.

Public catalog entries on Sciscape.

• supportsMeasured N1 maps reach 80% of reachable SEEG contacts with 2–5 stimulation sites in eight patients

  Our result agrees with it: the WM-pair term makes site plans better than random (7/8 patients, p = 0.023), while distance alone does not (5/8, p = 0.20). This agrees with more N1s from WM pairs after distance.

• challengesWhite-matter stimulation did not increase early SEEG response size in five subjects from OpenNeuro ds004696

  WM-site advantage after distance control did not replicate in ds004696 at 6 mA with a response-size measure.

• usesSOZ contacts showed no consistent distance-adjusted N1 change in 6 of 8 SEEG patients

  Input table results/pairs_contacts.json (expert N1 labels, distance, SOZ labels for ds005448) comes from this package.

• usesFive-pulse SEEG CCEP maps were less reliable than Spearman–Brown predictions across five patients

  We used its MAT v5 reader (mat5.py) and the expert N1sChecked label files that it fetched from the ds005448 derivatives.

• usesSame-shaft SEEG N1 responses were not consistent across 8 patients at equal distance (median OR 1.39; 5/8 above 1)

  We used its archived stimulated-pair x contact table (results/pairs_contacts.json: expert N1 labels, distances, tissue and same_shaft fields) from ds005448 as the only input.

• usesPre-stimulus band power did not predict single-trial N1 amplitude in 8 SEEG patients

  Showed the use of the expert-checked N1 labels (N1sChecked.mat, checked==1) as the response reference; we use them to select responding contacts.

• supportsWhite matter stimulation was associated with more early CCEP responses in eight Mayo SEEG patients

  It reported more CCEP responses from WM stimulation pairs than from GM pairs at equal distance in UMCU ds005448 (OR about 2.5). We find the same direction and a similar size at Mayo (ds004696, 8 patients, 6 mA biphasic): OR 1.97, 95% CI 1.35-2.79, which includes 2.5.

• supportsWhite-matter SEEG pairs showed more distance-adjusted N1 responses in 4 of 8 Mayo subjects (+0.104)

  Independent-center test: ds004696 gives a distance-adjusted white-matter effect of +0.104 (monopolar) and +0.072 (median reference), near the +0.084 found in ds005448.

• usesIn 8 SEEG patients, measured CCEP maps improved neighbor-site prediction only for pairs that shared a contact

  We re-used its archived ds005448 input subset (N1sChecked derivatives, electrodes/channels/events tables) with its SHA-256 list, and its numpy-only MAT v5 reader code/mat5.py.

• usesDistance from the stimulation site explains most of the N1 map overlap between SEEG stimulation sites; a small site-specific excess remains at 7.5-15 mm (8 patients, ds005448, binary expert N1 labels)

  Original source of the ds005448 v1.0.0 N1 table and its file hashes.

• challengesWhite matter stimulation advantages appear with referential but not bipolar recording in ds004696

  The ds005448 WM advantage is not found in ds004696 with bipolar recording pairs; its montage dependence must be tested.

• usesTissue labels predict distance-adjusted N1 reach in held-out patients; background spectra add no predictive value

  We use its expert-checked N1 extraction code (analyze.py, mat5.py) and its copy of the ds005448 input files.

• challengesIn one Mayo SEEG patient, white-matter stimulation did not increase distance-adjusted CCEP responses

  Its ds005448 result (WM stimulation pairs give more N1s after distance control) did not appear at a second center: in ds004696 sub-01 (Mayo, 6 mA biphasic), the distance-adjusted WM odds ratio was 0.87 (95% site-bootstrap CI 0.42-1.74, p = 0.71). One patient and one recording shaft, so this limits the generality, not the ds005448 finding itself.

• challengesWhite matter stimulation did not increase CCEP detection in one Mayo SEEG patient at equal distance

  We tested its white-matter stimulation effect (+0.084 at equal distance, ds005448) at a second center (Mayo ds004696 sub-01). The stratified difference was -0.004 (95% CI -0.16 to +0.15). This does not replicate the effect, but the CI includes it, so the challenge is weak (one patient, one recording shaft).

• usesIn 8 SEEG patients, geometry-based selection reached 80% of N1-reachable contacts with a median of 5 sites; measured-response oracle needed 3

  The input is the archived per pair-contact expert-checked N1 table (results/pairs_contacts.json, same SHA-256) from this package.