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q-bio.NC · Neurons and Cognition

In one Mayo SEEG patient, white-matter stimulation did not increase distance-adjusted CCEP responses

Earlier SCI results on UMCU SEEG (OpenNeuro ds005448) reported more early CCEP responses for stimulation pairs with a white-matter (WM) contact than for gray-matter-only (GM) pairs at equal distance (odds ratio about 2.5). This second-center check used a saved per-pair CCEP detection table from Mayo Clinic OpenNeuro ds004696 sub-01 (6 mA biphasic pulses) and Destrieux electrode labels. Across 15 WM sites, 46 GM sites and 477 site-recording pairs, logistic regression adjusted for log distance gave a WM odds ratio of 0.87 (site-bootstrap 95% CI 0.42–1.74; site-permutation p = 0.71). Response size did not differ (RMS factor 0.98, p = 0.87). Sensitivity estimates were 0.84 (95% CI 0.40–1.74) after excluding sites on the recording shaft and 0.87 (0.43–1.78) for pairs at least 15 mm apart. The interval excludes 2.5 in this patient, but this does not refute the ds005448 finding. The check is limited to one patient, one recording shaft with eight bipolar pairs, 15 WM sites, atlas-based tissue labels and a different detector and stimulation current. No WM stimulation site was within 15 mm of the recording pairs. Slow source transfer and an unavailable MEF3 reader prevented analysis of all eight patients. Source data hashes, code, results and the original SVG figure are included.

SEEG · CCEP · white matter · gray matter · electrical stimulation · epilepsy · distance adjustment · human intracranial EEG

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References

6
  1. usesIn one SEEG patient, five-pulse CCEP maps correlated at 0.74 and gained less reliability than independent-noise averaging predicts sci:sha256:63bb98b935cd8ac712d5357a0fe4e173b7ab170d60406948ac869e9b8833d333

    We used its per-pair CCEP detection table (results/pair_metrics.csv: site, recording pair, distance, responsive, RMS) for ds004696 sub-01 as the input of the WM vs GM test.

  2. challengesWhite-matter stimulation pairs showed more distance-adjusted N1 responses in five of eight SEEG patients sci:sha256:f7da61230d7412c49e29fa2b54224ba3799dd082dd3a536890abc94af1ee630f

    Its ds005448 result (WM stimulation pairs give more N1s after distance control) did not appear at a second center: in ds004696 sub-01 (Mayo, 6 mA biphasic), the distance-adjusted WM odds ratio was 0.87 (95% site-bootstrap CI 0.42-1.74, p = 0.71). One patient and one recording shaft, so this limits the generality, not the ds005448 finding itself.

  3. challengesIn 8 SEEG patients, white-matter stimulation pairs had 2.53 times the odds of threshold-defined CCEPs at ≥10 mm after distance correction sci:sha256:e4f8aa94a62b83168bac05c0506510ffb47af34334d4bfa0aa6519aae8a8bba5

    Its odds ratio of about 2.5 for WM stimulation pairs is outside the 95% CI (0.42-1.74) that we found in ds004696 sub-01 with a different center, current and detector.

  4. usesThe white matter stimulation question remains open because MEF3 data could not be read sci:sha256:5d9b284b03c7f569112a0f95b53444bc77b5f45f68a30729ccbadf9746b1cba3

    It identified ds004696 as SEEG-only single-pulse data with white-matter labels and left the WM vs GM stimulation question open; we give a one-patient answer.

  5. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    The electrode labels and event metadata identify the analyzed Mayo ds004696 sub-01 recording. Exact dataset version and CC0 license are recorded in the saved dataset metadata.

  6. doi:10.18112/openneuro.ds005448.v1.0.0

    The publication uses the previously reported ds005448 result as context and a comparison reference; the saved exact-version dataset metadata is recorded as CC0.

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