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Matched windows in 23 C. elegans worms showed no clear increase after light in the electrical count term for response correlation

We tested whether the relation between electrical anatomy and shared trial changes increases after single-neuron stimulation. We used fixed DANDI data and a reference C. elegans connectome. Three eight-second windows had equal twelve-second spacing. We centered target changes within repeated-source groups. The main panel had 4,209 animal and target-pair rows from 23 worms. A weighted linear model controlled animal, target identity and chemical wiring. The fitted correlation contrast from zero to two electrical sections was +0.157 before light and +0.142 after light. The direct after-minus-before contrast was -0.015, with a 95% range of -0.114 to +0.067 from 4,000 refitted animal bootstrap samples. All specified difference ranges included zero. The data support an electrical-count association already present before the current pulse. They give no clear evidence that this association increases after the pulse. They do not establish equal effects or a direct junction mechanism. An added algebra check shows why a positive baseline-adjusted coefficient need not imply an increase. The package preserves code, raw window means, fixed source keys, source URLs and hashes, all fits and bootstrap draws, figures, and repeat steps. No new neural measurements were collected.

electrical synapses · connectome · C. elegans · calcium imaging · trial correlation · matched windows · temporal specificity

Admitted 1 citing publication

References

6
  1. usesElectrical counts had a positive adjusted term for calcium response correlation in 23 C. elegans records, but repeat coverage changed the estimate sci:sha256:5bf1bb24d74104cc01bf6fbee0c70d840ca061284763832b34ae3d52ea035dc1

    We reuse the verified event keys, anatomical graph, source receipts, earlier pair table and MIT signal extraction code. We test its stated limit: its positive adjusted coefficient did not establish a rise above baseline.

  2. usesWiring features reduced calcium response error by 1.17% beyond cell identity in a fixed test across 103 C. elegans worms sci:sha256:0e5e26303629eecdd516b6e9419e39fd70425547e36bb717a69612e587e68861

    This study made the event keys and graph arrangement inherited through the repeat-response publication.

  3. usesdoi:10.48324/dandi.001075/0.240930.1859

    Fixed processed WT neural data. All 103 source files were checked against recorded SHA-256 values.

  4. usesdoi:10.1038/s41586-023-06683-4

    Original single-neuron stimulation and calcium-imaging study.

  5. usesdoi:10.1038/s41586-019-1352-7

    Source of the reference anatomical counts. We use the corrected July 2020 graph arrangement.

  6. doi:10.1073/pnas.2022599118

    Direct evidence that electrical synapses coordinate activity in a defined C. elegans circuit motivates the temporal comparison.

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