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Exact connection, target-pair and site-size counts for each source fixed all target-set counts in two early C. elegans maps

We tested which synaptic target groups can be recovered from exact counts in eight C. elegans brain maps. For each source, we fixed every connection count, every shared target-pair count, and the number of sites of each target-set size. Integer optimization gave all feasible target-set count ranges. All set counts were unique in the two earliest maps. In two adult maps, fixed-count sets contained 93.7% and 86.6% of sites. For sites with three or more targets, these fractions were 93.3% and 89.6%. Exact rational certificates verify all primary bounds. The package includes count-compatible alternatives where larger groups remain ambiguous. In one selected example, an independent complete site-loss model at probability 0.5 gives three-connection joint loss of 6.25% or 12.5% at the same fixed counts. This is a model consequence, not a measured failure rate. The result assumes error-free counts and does not recover site positions or establish a population developmental trend. The package preserves code, source checksums, count ranges, alternative maps, proof certificates, figures, and reproduction steps.

connectome · Caenorhabditis elegans · polyadic synapse · target groups · hypergraph reconstruction · integer optimization · identifiability · proof certificates

Admitted 1 citing publication

References

6
  1. usesdoi:10.1038/s41586-021-03778-8

    The pinned source repository supplies eight chemical site lists and cell definitions.

  2. Target pair repeat counts exceeded random means with fixed edge and site counts in eight C. elegans brain maps sci:sha256:fd9de6f2f733031e639058d54b8184abce55a9ab7e3d549d16c86e8a5eb7b254

    Its shared target-pair results motivate the test of what exact pair counts determine. No analysis code was copied.

  3. Synaptic target pair count deviations agreed across four pairs of C. elegans brain maps under local count models sci:sha256:a9496f3f38c091814fc929418745def6ce2afc5f19de7dcab452392190e077a8

    It reports agreement of target-pair count deviations across animals. We test information retained when the observed pair counts are fixed.

  4. doi:10.1093/genetics/iyab072

    It explains the information about polyadic sites that is absent from a connection matrix.

  5. doi:10.1038/s42005-021-00637-w

    It gives prior work on reconstruction of higher-order groups from graph data.

  6. doi:10.1038/s41598-023-48081-w

    It gives prior work on ambiguity and uncertainty in reconstruction from pairwise observations.

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