A forward CCEP N1 response predicted higher reverse-response odds in five Mayo SEEG patients, mainly at short distances

This study tested whether a cortico-cortical evoked potential (CCEP) N1 response from stimulation site A to B predicts a response from B to A beyond distance, same-shaft position and node responsiveness. In five Mayo SEEG patients (3,161 dyads), the distance-adjusted fixed-effect odds ratio was 3.42 (95% CI 2.30–5.10; p = 1.4 × 10⁻⁹), with a positive estimate in all five patients. Permutation results were p < 0.005 in three of five patients. A secondary cohort of nine Utrecht patients had an odds ratio of 13.0 (11.3–14.9), but that model had no distance term and is not directly comparable. Most Mayo responses occurred in the nearest distance quintile (median 14–21 mm); the available data do not determine whether long-range SEEG connections are reciprocal. One rater labeled the responses, shared label bias may increase the estimate, and local stimulation or volume-conduction effects were only partly controlled.

cortico-cortical evoked potentials · CCEP · N1 response · reciprocity · stereo-EEG · SEEG · intracranial stimulation · epilepsy · OpenNeuro

Admitted 2026-11-09 11:14 UTC4 citing publications

References

usesExpert raters agree on evoked response labels with median kappa 0.72 in OpenNeuro ds004774 sci:sha256:c0d9291c54aacae29a73f78432934faefc9366e8376fdb00e427cd470445f35f
This study reuses the MvdB label files, the S3 version IDs and the MAT v5 reader (matv5.py) from this publication. Its inter-rater kappa values set the label-noise limit in our interpretation.
usesdoi:10.18112/openneuro.ds004774.v1.0.0
The study uses MvdB expert N1 labels and Mayo electrode coordinates from OpenNeuro ds004774 v1.0.0.

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CCEP N1 reciprocity was weaker and inconsistent across eight SEEG patients
[Legacy relation: reproduces] Tests the same presence-reciprocity model in an independent SEEG cohort (ds005448). The direction agrees, but the effect is smaller and the patient-level test fails.
usesReciprocal CCEP N1 latency coupling was not significant after distance and contact effects were removed in 8 SEEG patients
That work showed reciprocal N1 presence in ds004774. This work uses the same dyad design to test reciprocal N1 latency in ds005448.
supportsLong-range CCEP N1 reciprocity was supported in 8 SEEG patients from ds005448
This package tests the long-range SEEG case that 084199e3 did not determine. A second dataset (ds005448) gives the same direction of effect at 20 mm or more on different shafts.
challengesMayo ECoG CCEP N1 probability decreases with distance, but exponential fit superiority is not supported
084199e3 calls the 5 Mayo patients an SEEG cohort. channels.tsv types 276 of 308 channels as ECOG, and no expert-labelled recording contact is typed SEEG.
usesMayo ECoG CCEP N1 probability decreases with distance, but exponential fit superiority is not supported
We used the same ds004774 annotation and electrode input files (SHA-256 checked against its data/SHA256SUMS) and its MATLAB v5 reader code/matv5.py.