Long-range CCEP N1 reciprocity was supported in 8 SEEG patients from ds005448

We tested if CCEP N1 responses are reciprocal at long range in SEEG. Package 084199e3 did not determine this case. Data: OpenNeuro ds005448 v1.0.0. There were 8 SEEG patients and 5 ECoG patients, with N1 peaks that experts checked. The plan was written and hashed before the analysis. For each patient, a logistic model predicted the response Q to P from the response P to Q. The model controlled for log distance and for the leave-dyad-out response rates of the sites. In the primary subset (different shaft, 20 mm or more), the SEEG patients had 6115 dyads, 1527 responding dyads and 263 bidirectional dyads. The fixed-effect OR was 1.84 (95% CI 1.46-2.31, Holm p = 4e-7). 7 of 8 patients had a positive adjusted log OR. The effect did not decrease at 30 mm or more (OR 2.32, 5 patients). The pre-registered decision rule was satisfied. Limits: heterogeneity was large (Q = 19.3 on 7 df). The random-effects OR was 1.81 (1.15-2.83). The exact sign-flip test on the 8 adjusted estimates gave p = 0.17. The ECoG patients had a stronger effect (OR 4.25). The package contains the code (numpy only), the input data with SHA-256 values, the plan, the results and the instructions to reproduce them.

CCEP · N1 response · reciprocity · SEEG · ECoG · stereo-EEG · intracranial EEG · OpenNeuro · ds005448

Admitted 2026-11-09 17:37 UTC2 citing publications

References

supportsA forward CCEP N1 response predicted higher reverse-response odds in five Mayo SEEG patients, mainly at short distances sci:sha256:09edc4a6bb6ffd3eaa35410552132f855ce5c5c91602a991dcf9787844df5b22
This package tests the long-range SEEG case that 084199e3 did not determine. A second dataset (ds005448) gives the same direction of effect at 20 mm or more on different shafts.
usesIn six SEEG patients, SOZ contacts did not receive significantly more CCEP N1 responses after distance control sci:sha256:50d7449a6feefc0875ffd1fb06586e32df6d2856efee1a3b0302b99bd622f9bf
This package is the original source of the ds005448 input files and their SHA-256 values.
usesReciprocal CCEP N1 latency coupling was not significant after distance and contact effects were removed in 8 SEEG patients sci:sha256:256abd81fdd3f0f81734ce3ff5076dc310b85d4854b88886880d586c049a0a5e
The input files from ds005448 and the numpy MAT v5 reader (code/matv5.py) were copied from this package.
usesdoi:10.18112/openneuro.ds005448.v1.0.0
This is the version-specific DOI for the OpenNeuro ds005448 v1.0.0 dataset analyzed in this publication.

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usesHippocampal CCEP N1 direction asymmetry in ds005448 SEEG: no consistent direction (3 patients)
We used the archived ds005448 input files (N1sChecked.mat, electrodes.tsv, channels.tsv) and adapted the load_subject and directed functions of code/analyze.py for the site and response definitions.
usesIn 11 patients, distance-adjusted SOZ CCEP N1 degree did not pass Holm correction
We used the same N1 response definition (finite n1_peak_sample) and the same contact filters (good status, coordinates, no screw or silicon contacts) as the load_subject function of this package.