Hippocampal CCEP N1 direction asymmetry in ds005448 SEEG: no consistent direction (3 patients)

We tested if expert-checked CCEP N1 responses between a hippocampal stimulation site and a neocortical gray-matter site occur more frequently in one direction. The data are the archived ds005448 SEEG inputs. The test plan was written and hashed before the analysis. Only 3 of 8 SEEG patients had a stimulated hippocampal site and 5 or more one-direction dyads. The pooled counts were equal: 34 dyads had only the hippocampus-to-cortex response and 34 dyads had only the cortex-to-hippocampus response. The per-patient log odds were -1.30, +2.53 and -2.40. The sign-flip p was 1.0, and the random-effects estimate was -0.37 (95% CI -3.58 to 2.84). Amygdala sites had more amygdala-to-cortex responses in all 3 tested patients, but this was not significant (Holm p 0.75). Limits: 3 patients give a minimum exact p of 0.25, the stimulated sites were chosen clinically, and the labels are those of the source dataset.

CCEP · N1 response · hippocampus · neocortex · stereo-EEG · directional connectivity · epilepsy