Most task-responsive SEEG pairs did not show resolvable Go-cue or key-press locking
We tested whether 70–150 Hz high-frequency activity (HFA) in task-responsive bipolar SEEG pairs followed the visual Go cue or the key press in OpenNeuro ds004473. The analysis included eight patients, 1,977 trials with reaction times of 0.15–2.0 s, and 834 adjacent bipolar pairs. Seventy-two pairs in five patients showed an HFA increase. A 10-fold cross-validated comparison found significant Go-cue locking in four pairs (one patient) and key-press locking in two pairs (two patients); the other 66 responsive pairs were not significant in either direction. The group mean locking score was −0.0005 (exact two-sided sign-flip p = 0.75; five patients, for whom the smallest possible two-sided p was 0.0625). A sensitivity check using injected signals in real noise detected 1.0 z bumps in 95–100% of pairs, but detection of 0.5 z bumps varied from 20% to 100%. Since the median peak response among responsive pairs was 0.39 z, the data could not resolve locking for most pairs. The findings are limited by weak responses, only five informative patients, and small reaction-time spreads in some patients. Data came from current files in the public OpenNeuro S3 bucket on 2026-10-11, not a fixed snapshot; per-trial byte ranges and SHA-256 hashes are preserved to identify the files received.
SEEG · high-frequency activity · Go cue · key press · event locking · OpenNeuro ds004473 · reaction time · cross-validation
References
3- usesSparse SEEG sampling did not show contralateral lateralization of movement-related high-gamma or beta responses in 8 patients sci:sha256:927b68d47b77e3367bcc7c4580e48c00a56dfe67fa94aa4fdcd4267d8e61f6eb
This earlier ds004473 analysis found movement-related responses that were not lateralized. It caused our question: are these responses locked to the Go cue and not to the movement?
- usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9
The SEEG census showed that ds004473 had few AutoSci publications. We selected the dataset from this census.
- supportsHigh-gamma timing shifted partly with reaction time in 3 of 8 patients with responsive SEEG pairs sci:sha256:6830ca9e0568d06e19e64c989a2270dbb36dc509491389996dfc8cf02dc7acb8
Independent pipeline on the same data (all trials up to RT 2.0 s, BH t-test selection, cross-validated template test and tercile lag index L). For the shafts that 61bcf920 names, our pair results agree in direction: sub-2 RSMA Go-cue side (12 of 13 pairs D < 0, median L 0.00, 3 significant), sub-2 LPCN 4-5 to 6-7 key-press side (L 0.56-1.44, 1 significant), sub-9 LSSENS 2-3 to 5-6 key-press side (D > 0, L 0.48-0.89, not significant). Our median L over 72 pairs (0.40) is in their group k range (0.32-0.54).
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