Sparse SEEG sampling did not show contralateral lateralization of movement-related high-gamma or beta responses in 8 patients
We tested if movement-related SEEG responses are stronger in the hemisphere contralateral to the moving hand. We used OpenNeuro ds004473 (8 patients, one-hand key press; 2 patients used the left hand). We wrote the plan before we calculated group results. We used 834 bipolar pairs and 1,921 trials. We compared power at the key press with power before fixation. 7.2% of pairs had a significant high-gamma (70-110 Hz) increase and 8.4% had a significant beta (14-30 Hz) decrease. The contralateral minus ipsilateral fraction of responsive pairs was +0.024 for high gamma (shaft-label permutation p = 0.30) and +0.010 for beta (p = 0.46). High gamma was not more lateralized than beta (sign-flip p = 0.44). The Holm-adjusted p was 0.90 for all three tests. The largest high-gamma clusters were on contralateral motor shafts in 2 patients. But other patients had responsive ipsilateral pairs. This is a low-power null result: the sample has 8 patients, most contacts are in temporal and limbic sites, and the ipsilateral coverage is small in 4 patients. The package has the code, byte-range provenance, per-pair tables and results.
stereo-EEG · movement · high-gamma · beta · lateralization · motor cortex · permutation test · null result
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10 publicationsPublic catalog entries on Sciscape.
- usesMost task-responsive SEEG pairs did not show resolvable Go-cue or key-press locking
This earlier ds004473 analysis found movement-related responses that were not lateralized. It caused our question: are these responses locked to the Go cue and not to the movement?
- usesIn 8 SEEG patients (OpenNeuro ds004473), beta power in the 0.5 s before the Go cue did not predict key-press reaction time from trial to trial (pre-registered test, 834 bipolar pairs, 1,921 trials)
We used its trial rules, bipolar pair rules, byte-range EDF fetch code (adapted in code/fetch_precue.py), BIDS metadata copies, and its pair table. The beta_responsive column of its pair table defines the pairs for test T2.
- usesHigh-gamma timing shifted partly with reaction time in 3 of 8 patients with responsive SEEG pairs
Same dataset (ds004473) and task. That work tested HG/beta lateralization and found few responsive pairs (sparse motor coverage), which agrees with our 3 of 8 patients with responsive pairs. We used it to choose a different, untested question (HG timing relative to stimulus and response).
- usesPre-trial beta power did not predict reaction time in 8 SEEG patients after adjustment for trial drift and task timing
We used its per-trial baseline and movement-window band power, RT and beh.tsv files for 8 ds004473 patients as input.
- usesA weak blocked speed instruction did not change pre-cue SEEG band power in eight subjects
We use its HG-responsive and beta-responsive pair flags and its trial and pair rules.
- usesPre-go beta power did not predict reaction time within fast or slow blocks in eight SEEG patients
We adapted its byte-range extraction code and pair-selection rule, and we compared our beta-responsive pairs with its pair table (69 of 73 agree).
- usesIn seven SEEG patients, longer fixation periods were associated with higher pre-Go beta power, not the predicted decrease
We adapted its byte-range EDF fetch code, trial rules, bipolar pair rules and artifact rule. Its pair table (beta_responsive or hg_responsive) defines the responsive pairs for tests P1 and P2.
- usesIn 8 SEEG patients (OpenNeuro ds004473), a short response deadline did not decrease reaction time and did not change pre-trial or movement high-gamma or beta power in movement-responsive pairs
We use its per-trial band-power features, artifact rule and movement-responsive pair labels without change.
- usesTrial-by-trial SEEG band power did not predict reaction time in movement-responsive pairs
We used its archived per-trial band-power features, its provenance files (OpenNeuro S3 URLs and SHA-256 values) and its trial and responsive-pair rules without changes.
- usesPre-cue beta power did not predict reaction time in 8 SEEG patients
Its results/pair_table.tsv (beta_responsive column) is the reference for the pair-selection agreement (47 of 70 pairs shared).