Chemical synapse count gave no clear response-magnitude order in 548 selected worm neuron pairs

We tested whether the direction with more chemical synapses has the larger absolute mean evoked calcium response within a neuron pair. We linked two adult Witvliet anatomy maps to the Randi WT atlas by cell name. In 548 selected pairs with at least three occurrences per direction, the rule agreed in 267 pairs (48.72%). A nominal 95% neuron-resampling interval was 41.01% to 56.58%. Agreement was 48.24% in 313 pairs with the same nonzero count order in both adults. Adding chemical count imbalance to neuron identity and occurrence controls changed held-out log loss from 0.722259 to 0.724030. The reduction was -0.001771, with a conditional interval of -0.007379 to 0.002521. This is a null result for a limited direction rule and model. It does not show equal function or no anatomy prediction value. Different animals, noisy mean responses, selected coverage, indirect routes and two anatomy samples limit the test. Code, pair tables, predictions, hashes and a figure support reproduction.

C. elegans · connectome · signal propagation · direction agreement · null result