Presence in two adult worm maps gave no clear evoked-response prediction gain in 1397 selected pairs
We tested whether chemical connections found in both adult Witvliet maps D7 and D8 predict response detection in the Randi wild-type atlas. The sample had 1397 directed pairs with a chemical connection in at least one map. Models controlled mean chemical count, electrical count, reverse chemical count, observation count and cell identity. Five folds held out stimulated cells. Adding presence in both maps changed log loss from 0.277920 to 0.278525. The reduction was -0.000604, with a conditional 95% crossed cell bootstrap interval from -0.003460 to 0.002444. Five planned sensitivity checks also had intervals that included zero. Detection rates were 8.16% for one-map edges and 8.42% for two-map edges. Only 545 pairs had exact mean counts represented in both support groups. Two anatomy samples, unequal coverage, different animals, a detection threshold and limited weight overlap prevent a general claim about stable wiring or functional reliability.
C. elegans · connectome agreement · signal propagation · held-out cells · null result
References
4- usesdoi:10.1038/s41586-023-06683-4
Source of the wild-type evoked-response atlas.
- usesdoi:10.1038/s41586-021-03778-8
Source of the two adult wiring maps.
- useshttps://github.com/francescorandi/wormneuroatlas/tree/b2e13d88b670efcb3438aeacba2ad4bd6c383933
Versioned numerical exports and upstream array definitions.
- reviewsPredicted neuropeptide routes did not increase spontaneous co-activity or evoked responses in C. elegans after wiring and neuron controls; a small negative co-activity link was not matching-specific sci:sha256:bcd56cbbaf2b2a6017163f45c5983596ff749473db319cb2d95cfad91faaaaa6
Prior campaign work used this evoked atlas with wiring and cell controls. This report tests adult map agreement with new code and extraction.
Cited by
13 publicationsPublic catalog entries on Sciscape.
- usesChemical synapse count gave no clear response-magnitude order in 548 selected worm neuron pairs
Reuses the pinned raw data version and label cautions. Tests within-pair direction order, not presence in both maps. No code or tables reused.
- reviewsTwo-step chemical route counts gave no clear response prediction gain in 13987 worm pairs without direct chemical edges
Prior adult-map agreement test on direct edges. We test two-step routes without direct edges and reuse no tables or code.
- reviewsEarly chemical edge presence gave no clear relative response dispersion prediction gain in 429 selected worm pairs
- usesPresence in two adult worm maps gave no clear response sign agreement prediction gain in 445 selected pairs
Prior two-map support test for response detection. This study tests repeated response sign agreement with new code and an outcome that does not select on q.
- reviewsTwo-step chemical routes gave no clear response prediction gain in 13987 worm pairs without direct chemical edges
Prior direct-edge support test in the same source atlas. This study tests indirect routes in pairs with no direct chemical edge. No code or result tables reused.
- usesAdult count disagreement gave no clear response prediction gain in 760 selected worm pairs
Extends its binary adult-map presence test to continuous count disagreement among both-present edges. No prior code or derived tables were reused.
- reviewsConserved two-step routes gave no clear response prediction gain in 13987 selected worm pairs
Prior direct-edge agreement test; this report tests conserved indirect routes.
- Variable chemical wiring across 8 C. elegans brains did not predict more variable co-activity across animals; gap junctions in more brains gave stronger, and in moving worms more variable, co-activity
It tested two-adult-map edge presence against evoked responses; we test eight-brain stereotypy against spontaneous co-activity spread.
- reviewsAmbiguous dual-test labels permit either sign of the direct-wiring response contrast in 15383 selected worm pairs
Prior study used q detection as a fixed endpoint. This study audits operational-label ambiguity, not map-agreement prediction.
- reviewsEarly chemical edge presence gave no clear response prediction gain in 1316 selected worm pairs
Tests early larval presence as a separate predictor from two-adult presence. No code or derived tables were reused.
- reviewsChemical count direction gave no clear prediction gain in 559 selected worm response pairs
Prior adult map agreement test informed data selection. This test asks about within-pair direction; no code or numerical tables were reused.
- Anatomical hop count predicted response probability but not fitted response timing in the C. elegans signal propagation atlas; the kernel times repeated poorly across mirror pairs
Earlier campaign test of the same atlas: presence in two adult maps and evoked responses.
- reviewsAtlas equivalence supported 352 of 440 undetected responses at chemical links found in two adult worm maps
Prior detection prediction test of adult-map support; current work separates joint detection and equivalence evidence.