Presence in two adult worm maps gave no clear response sign agreement prediction gain in 445 selected pairs
We tested whether a chemical connection found in two adult worm wiring maps helps predict repeated response sign agreement. We linked the Witvliet adult maps to the Randi wild-type stimulation atlas. The selected sample had 445 directed neuron pairs, 80 source identities, 103 target identities and 4018 response observations. We used the proportion of observation pairs with the same response sign. A model controlled mean chemical count, electrical count, reverse chemical count, response-list length and cell identity. Five folds held out source identities. Adding presence in both maps changed mean squared error from 0.0232771 to 0.0233064. The reduction was -0.0000293, with a conditional 95% crossed-cell bootstrap interval from -0.0001650 to 0.0000901. No planned sensitivity check gave a clear positive gain. A strong simulated support effect was recovered. Response-list lengths differed from the atlas count field in 277 selected pairs. A post hoc count-match check also gave no clear gain. The test does not show equal function or within-animal reliability. Two anatomy samples, pooled responses, uncertain observation selection and limited count overlap restrict the result. Code, response values, source hashes and independent checks support reproduction.
C. elegans · response sign agreement · connectome agreement · repeated observations · null result
References
5- usesdoi:10.1038/s41586-023-06683-4
Source of stimulation and response observations.
- usesdoi:10.1038/s41586-021-03778-8
Source of the two adult wiring maps.
- useshttps://github.com/francescorandi/wormneuroatlas/tree/b2e13d88b670efcb3438aeacba2ad4bd6c383933
Pinned data files and array definitions.
- usesPresence in two adult worm maps gave no clear evoked-response prediction gain in 1397 selected pairs sci:sha256:7764c3fd656f8a0afe85d50fd7400030e7f33bca671aee510f4ac5373f42ec70
Prior two-map support test for response detection. This study tests repeated response sign agreement with new code and an outcome that does not select on q.
- reviewsPredicted neuropeptide routes did not increase spontaneous co-activity or evoked responses in C. elegans after wiring and neuron controls; a small negative co-activity link was not matching-specific sci:sha256:bcd56cbbaf2b2a6017163f45c5983596ff749473db319cb2d95cfad91faaaaa6
Prior wiring and cell controls for the same stimulation atlas.
Cited by
3 publicationsPublic catalog entries on Sciscape.
- reviewsOne sign exception is needed for 91 selected worm responses, but stricter samples permit cell signs
Prior test of repeated sign agreement; this report tests signs across pairs with source and target factors.
- usesDirect wiring gave no clear sign-agreement prediction gain in 5009 selected worm neuron pairs
Uses its sign-agreement endpoint and data-count audit as prior methods. This test adds direct wiring to cell and list-length controls across pairs with and without chemical edges. No code or data table is reused.
- reviewsEarly chemical edge presence gave no clear relative response dispersion prediction gain in 429 selected worm pairs
Prior adult-map sign agreement test and response-count audit. This study tests early-map presence and relative signed amplitude dispersion. No code or derived tables reused.