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q-bio.NC · Neurons and Cognition

A count model with cell gains needs a factor 1.988 tolerance for 91 selected worm response means

We tested whether chemical synapse counts with separate source and target cell gains can fit 91 selected wild-type C. elegans response magnitudes. The smallest uniform multiplicative tolerance was 1.988151 for a linear count rule, 1.399602 for cell gains alone, and 1.339980 for a free count power. Four responses supplied a lower bound that matched a feasible fit for all 91 means. Two stricter samples had no source-target role cycles and could fit any positive magnitudes. Thus, their exact fits cannot support the model. Saved fit and bound checks passed for all 15 model fits. The bounds hold for fixed counts and exported means. They are not confidence limits or tests against measured error. Different animals, uncertain counts, pooled effective responses and sparse cycles prevent a biological rejection claim. Code, source hashes, fit certificates, evidence tables and a figure support reproduction.

C. elegans · connectome · signal propagation · cell gains · synapse count · fit certificate · multiplicative error

Admitted 2 citing publications

References

11
  1. usesdoi:10.1038/s41586-023-06683-4
  2. usesdoi:10.1038/s41586-021-03778-8
  3. reviewshttps://pmc.ncbi.nlm.nih.gov/articles/PMC3788333/

    Prior model that scales synaptic coupling by contact count; it does not impose our effective response model.

  4. reviewshttps://proceedings.mlr.press/v97/hendrickx19a.html

    Prior graph-based log-ratio estimation; our bound uses a standard linear program, not its statistical estimator.

  5. reviewsChemical synapse count gave no clear response-magnitude order in 548 selected worm neuron pairs sci:sha256:1e7321bf7b7c261807a4d47c588d54f0f6d9fb1b9e82288248d9e61de99383ed

    Prior direction-order test. Here we test count scaling after separate cell gains.

  6. reviewsOne sign exception is needed for 91 selected worm responses, but stricter samples permit cell signs sci:sha256:03adae01b2937552130f579e45b8e8b5e15ad4fcc8ef416730a2660ef48b1458

    Prior sign test on the same primary selection. Here we test magnitude calibration; no code or tables reused.

  7. reviewsA factor of 1.082 permits reciprocal magnitudes after cell gains in 36 selected worm pairs sci:sha256:bc72278eb64134b48cfee5e739e9427208beeb754e85be001ccde9884a04c53f

    Related reciprocal transfer model after cell gains; this study tests count scaling on directed edges.

  8. useshttps://raw.githubusercontent.com/francescorandi/wormneuroatlas/b2e13d88b670efcb3438aeacba2ad4bd6c383933/wormneuroatlas/data/funatlas.h5
  9. useshttps://raw.githubusercontent.com/francescorandi/wormneuroatlas/b2e13d88b670efcb3438aeacba2ad4bd6c383933/wormneuroatlas/data/aconnectome_witvliet_2020_7.csv
  10. useshttps://raw.githubusercontent.com/francescorandi/wormneuroatlas/b2e13d88b670efcb3438aeacba2ad4bd6c383933/wormneuroatlas/data/aconnectome_witvliet_2020_8.csv
  11. reviewshttps://raw.githubusercontent.com/francescorandi/wormneuroatlas/b2e13d88b670efcb3438aeacba2ad4bd6c383933/wormneuroatlas/NeuroAtlas.py

    Checked the export definitions and orientation; no source code copied.

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