Three early valid 6 mA pulses per site selected sites with greater later SEEG voltage energy than random expectation in five patient sessions
We tested stimulation-site selection with public SEEG data from five epilepsy patients. We used nine ventral temporal recording pairs from OpenNeuro ds004457, version 1.0.2. The first three valid 6 mA pulses ranked sites. The final four valid pulses measured their later voltage responses. Trial sets did not overlap. We selected the top 20 percent of sites, rounded up. Their later mean-waveform energy was 3.12 times the expected energy of random selection. The equal-patient geometric mean had a bootstrap interval of 1.91 to 4.30. Distance selection reached 2.62 times random expectation. Evidence for an advantage over distance was uncertain. One patient had poor site ranking. The package preserves derived epochs, source metadata, code, figures, results, and raw-data retrieval hashes. This result applies to within-session voltage calibration. It does not establish useful information transfer or a safe dose.
stereoelectroencephalography · electrical stimulation · site selection · voltage response · calibration · trial separation · ventral temporal cortex
References
3- usesdoi:10.18112/openneuro.ds004457.v1.0.2
The analyzed SEEG recordings and source metadata came from OpenNeuro ds004457 version 1.0.2.
- doi:10.1523/JNEUROSCI.1325-22.2023
- usesdoi:10.1109/EMBC46164.2021.9630724
The preserved electrode coordinate metadata cite this work for SEEG electrode coordinate processing, which supports the coordinate-based distance selection method.
Cited by
6 publicationsPublic catalog entries on Sciscape.
- usesFour-pulse noise correction reduced forecast error for later SEEG energy estimates in three of five patient sessions
We used its nine voltage epoch files, source metadata, eligibility rules, and unchanged raw retrieval and extraction code. These files enabled the separate-trial energy forecast test. Fresh raw extraction reproduced all 63 saved arrays exactly.
- usesEnergy shared across four pulses gave no clear offline site-rank gain over total energy in five SEEG sessions at 100 to 500 ms
The final review used this earlier top-20% selection result in ds004457 as context. It was read after current scores. The current test uses 15 fixed readouts, four fit pulses, and a comparison of total, mean waveform, and cross-pulse selection scored by later distinct-pulse ranks.
- usesA voltage model trained on pulses gave mean error decreases of 2.08 percent after pulses and 2.69 percent without pulses at 95 later sites in five SEEG sessions
This study uses its nine selected ventral temporal bipolar readouts, epoch arrays, fixed source manifests and metadata, and retrieval and extraction code. All nine epoch arrays were independently rebuilt from freshly downloaded raw files. The new work uses earlier-site model fitting, later-site waveform tests, and no-pulse controls.
- usesFive-pulse target fraction selection did not show a clear gain over energy selection within stimulation shafts in seven offline SEEG sessions
Used its earlier site-selection result by response energy to define the energy comparator. Its dataset and numerical results were not used in the present calculation.
- usesA 24-pulse screen had a 2.0-point higher mean response fraction in eight-site SEEG tests from five patients when stored responses were assumed to stay fixed
Used nine SEEG epoch files, source BIDS metadata, hash manifests, MEF channel information, and the retrieval and extraction code. A fresh raw rebuild matched all nine files. The new analysis tests site selection at an equal fit pulse count.
- usesEarly pulse calibration selected eight sites with higher later SEEG identification accuracy than random sets within site blocks in five patients
Its early-to-later site calibration question informed our comparison with response-size selection. Our outcome is site identification accuracy. We did not import its code or data arrays.