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q-bio.NC · Neurons and Cognition

A fixed gamma model gave mean within-shaft AUC 0.818 for SOZ marks in 14 SEEG patients excluded from fitting

We tested whether gamma decrease after seizure end adds rank information to onset gamma. SOZ means the clinical seizure onset zone. The source was public SEEG dataset ds004100, version 1.1.3. We fit fixed models on run 01 from 15 patients. We tested run 02 from 14 other patients. The combined model gave mean within-shaft AUC 0.818, versus 0.649 for onset gamma alone. The mean patient gain was 0.169. Its descriptive 95% interval was 0.003 to 0.351, conditional on the fitted models. The exact sign-flip test gave p = 0.0947265625 under independent, symmetric null patient gains. Six patients improved, five worsened, and three tied. Population improvement remains uncertain. A post-plan fixed-sum comparison gave AUC 0.809. The fitted model gain over that score was 0.009, with interval -0.012 to 0.033. Earlier work on this cohort informed the question. Pair selection used clinical labels. The study does not establish treatment benefit. All 64 inputs were rebuilt from pinned public raw ranges. All 320 range hashes and saved arrays matched. The package preserves code, compact data, provenance, patient results, and repeat instructions.

seizure onset zone · stereoelectroencephalography · gamma power · intracranial EEG · AUC · patient-level validation

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References

7
  1. usesThe patient bootstrap interval included zero added SOZ rank gain from post-seizure gamma in 29 ds004100 SEEG patients under independent, exchangeable patient sampling sci:sha256:b94a9999309dc31bf687f61124d6c949c4bf5405535ab70149d25d622df9c352

    We used its report to compare training rules and uncertainty in the discussion. It was read after our primary analysis. It did not determine our fit or test rules.

  2. usesThe gamma difference from onset to 10–30 seconds after seizure end gave mean within-shaft SOZ AUC 0.833 versus 0.747 for onset increase in 29 SEEG patients sci:sha256:78ade56be9e5825ede2eb7829e5ccb1f65903176943bbe01ebcce4bc4df2caee

    Its fixed onset-to-post-seizure gamma score led to our post-plan descriptive fixed-sum check on the frozen primary test set. It did not change the primary comparison.

  3. usesChoice among 12 scores gave a mean AUC gain of 0.011 in separate seizures from 29 ds004100 SEEG patients sci:sha256:33e4e621d074278abcce1fbf1ef462f526bdf5f640d2b9f2f743e687d17d9398

    We inherited its fixed 32-patient selection and EDF transport layout through the direct parent. We did not use its earlier power measurements.

  4. usesGamma decrease 10–30 seconds after seizure end gave mean within-shaft AUC 0.790 for SOZ marks in 29 ds004100 SEEG patients sci:sha256:99be67b99ddbb5d8f4a313e37c0796d3d1720b9c5256eb23bdc178856757d497

    We used its 64 gamma power files, raw fixture, source pins, clinical metadata, and extraction code. Its aggregate result informed the question.

  5. usesThe 95% patient interval included zero AUC gain from added post-seizure gamma rank weights of 0% to 50% in separate seizures from 29 SEEG patients under independent, exchangeable patient sampling sci:sha256:c78ba9a44b1dcc1bcf6185b4c6e5c859261a02c45cdbe443e0ecb84c4a8227b2

    We used its separate-seizure weight-selection result as discussion context. It was read after our primary analysis and did not determine our model settings.

  6. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    The analyzed power files and source records come from OpenNeuro ds004100 version 1.1.3; source version, commit, pins, and hashes are preserved.

  7. doi:10.3389/fneur.2026.1862336

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